E3 Ligases

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Single-subunit
E3 Ligases

Multi-subunit
E3 Ligase Complexes

Accessory
Proteins

PROTACs and Targeted
Protein Degradation

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Single-subunit E3 Ligases

These single subunit E3 ligases are capable of ubiquitinating protein substrates in vitro when supplied with ubiquitin, E1, an appropriate E2, and ATP. These include enzymes from the RING, U-box, HECT and RBR class E3’s.

cIAP-1/HIAP-2	Livin alpha/BIRC7	Parkin
cIAP-2/HIAP-1	MDM2/HDM2
E6AP/UBE3A	NEDD4

Multi-subunit E3 Ligase Complexes

Many E3 ligases are assembled from multiple subunits, in many cases consisting of a substrate receptor, an adaptor(s), a cullin and a RING. These include enzymes from Skp-Cul1-Fbox, Elongin-Cul2/5-SOCS box, DCAF-Cul4 and others E3 classes. Some products are capable of ubiquitinating protein substrates in vitro when supplied with ubiquitin, E1, an appropriate E2, and ATP. Others are purified substrate receptors for use in binding studies.

CUL1/RBX1	CUL4A/RBX1/DDB1/CRBN	SKP1/FBXO7/CUL1/RBX1
CUL2/RBX1	CUL5/RBX2	VHL/ELOB/ELOC/CUL2/RBX1
CUL3/RBX2	DDB1/CRBN
CUL4A/RBX1	Elongin B/C-VHL

Accessory Proteins

Accessory proteins include E3 ligase co-factors such as kinases and heat shock proteins. Also included are E3 ligase substrates and proteins for research in aggresomal disorders.

BRD4	HSP90 alpha	Tau
HSP40/DNAJB1	PINK1	TDP-43/TARDBP
HSP70/HSPA1A	alpha-Synuclein	Viral HPV E6

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