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E 7820

Catalog #: 6785 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
6785/50
6785/10
E 7820 | CAS No. 289483-69-8 | Integrin Receptor Inhibitors
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Description: α2 integrin inhibitor; anti-angiogenic

Chemical Name: 3-Cyano-N-(3-cyano-4-methyl-1H-indol-7-yl)benzenesulfonamide

Purity: ≥98%

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Biological Activity

E 7820 is a α2 integrin inhibitor. Inhibits angiogenesis in vitro (IC50 = 0.11 - 0.25 μM). Also inhibits growth of human colorectal cancer cell lines. Enhances efficacy of erlotinib in a non-small-cell lung cancer xenograft model. Also acts as a molecular glue to induce proteosomal degradation of mRNA splicing factor RBM39.

Technical Data

M.Wt:
336.37
Formula:
C17H12N4O2S
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
289483-69-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Sulfonamide derivative, E7820, is a unique angiogenesis inhibitor suppressing an expression of integrin α2 subunit on endothelium.
    Funahashi et al.
    Cancer Res., 2002;62:6116
  2. Enhanced anti-angiogenic effect of E7820 in combination with erlotinib in epidermal growth factor receptor-tyrosine kinase inhibitor-resistant non-small-cell lung cancer xenograft models.
    Ito et al.
    Cancer Sci., 2014;105:1023
  3. Selective degradation of splicing factor CAPERα by anticancer sulfonamides.
    Uehara et al.
    Nat.Chem.Biol., 2017;13:675

Product Datasheets

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