Home / Active Degraders / dTRIM 24

dTRIM 24

Catalog #: 6607
1 Citation Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
6607/5
dTRIM 24 | CAS No. 2170695-14-2 | Active Degraders
1 Image
Description: TRIM24 Degrader (PROTAC®)

Chemical Name: (2S,4R)-1-((S)-15-(tert-Butyl)-1-(3-(N-(1,3-dimethyl-2-oxo-6-(3-propoxyphenoxy)-2,3-dihydro-1H-benzo[d]imidazol-5-yl)sulfamoyl)phenyl)-1,13-dioxo-5,8,11-trioxa-2,14-diazahexadecan-16-oyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide

Purity: ≥98%

Product Details
Citations (1)
Reviews
Biological Activity Technical Data Additional Information Background Product Datasheets Calculators

Biological Activity

dTRIM 24 is a degrader (PROTAC®) composed of the TRIM24 ligand IACS-9571 conjugated to a VHL ligand. Displays dose- and time-dependent degradation of TRIM24 in cells, with maximum degradation achieved at 5 μM. Degradation phenotypically mirrors genetic deletion of TRIM24. Demonstrates antiproliferative effects in MOLM-13 cells. Cell permeable.

PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.

Technical Data

M.Wt:
1113.3
Formula:
C55H68N8O13S2
Solubility:
Soluble to 20 mM in DMSO and to 20 mM in ethanol
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
2170695-14-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold under license from Dana-Farber Cancer Institute

Background References

  1. Functional TRIM24 degrader via conjugation of ineffectual bromodomain and VHL ligands.
    Gechijian et al.
    Nat.Chem.Biol., 2018;14:405

Product Datasheets

Reconstitution Calculator
Molarity Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Molarity Calculator

=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Citation for dTRIM 24

The citations listed below are publications that use Tocris products. Selected citations for dTRIM 24 include:

1 Citation: Showing 1 - 1

  1. Engineered PROTAC-CID systems for mammalian inducible gene regulation
    Authors: Ma Et al.
    J Am Chem Soc  2023;145:1593

FAQs

No product specific FAQs exist for this product, however you may

View all Small Molecule FAQs

Reviews for dTRIM 24

There are currently no reviews for this product. Be the first to review dTRIM 24 and earn rewards!

Have you used dTRIM 24?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review
Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.