Dexrazoxane hydrochloride

Catalog # Availability Size / Price Qty
3857/10
3857/50
Dexrazoxane hydrochloride | CAS No. 1263283-43-7 | DNA Topoisomerase Inhibitors
1 Image
Description: Topoisomerase II inhibitor
Alternative Names: ICRF-187

Chemical Name: 4-[(2S)-2-(3,5-Dioxopiperazin-1-yl)propyl]piperazine-2,6-dione hydrochloride

Purity: ≥98%

Product Details
Citations (1)
Reviews

Biological Activity

Dexrazoxane hydrochloride is a topoisomerase II inhibitor and intracellular ion chelator. Bridges and stabilizes an interface between two ATPase promoters to inhibit topoisomerase II activity. Cardioprotective when co-administered with doxorubicin; decreases formation of reactive oxygen species (ROS) and activates the PI3K/Akt survival pathway.

Technical Data

M.Wt:
304.73
Formula:
C11H16N4O4.HCl
Solubility:
Soluble to 100 mM in water and to 100 mM in DMSO
Purity:
≥98%
Storage:
Desiccate at RT
CAS No:
1263283-43-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Dexrazoxane prevents doxorubicin-induced long-term cardiotoxicity and protects myocardial mitochondria from genetic and functional lesions in rats.
    Lebrecht et al.
    Br.J.Pharmacol, 2007;151:771
  2. Structure of the topoisomerase II ATPase region and its mechanism of inhibition by the chemotherapeutic agent ICRF-187.
    Classen et al.
    Proc.Natl.Acad.Sci., 2003;100:10629
  3. Sublethal doses of an anti-erbB2 antibody leads to death by apoptosis in cardiomyocytes sensitized by low prosenescent doses of epirubicin: the protective role of dexraz.
    Spallarossa et al.
    J.Pharmacol.Exp.Ther., 2010;332:87

Product Datasheets

Or select another batch:
View Batch
Reconstitution Calculator
Molarity Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Molarity Calculator

=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Citation for Dexrazoxane hydrochloride

The citations listed below are publications that use Tocris products. Selected citations for Dexrazoxane hydrochloride include:

1 Citation: Showing 1 - 1

FAQs

No product specific FAQs exist for this product, however you may

View all Small Molecule FAQs

Reviews for Dexrazoxane hydrochloride

There are currently no reviews for this product. Be the first to review Dexrazoxane hydrochloride and earn rewards!

Have you used Dexrazoxane hydrochloride?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review
Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.