DC 260126

Catalog #: 5357 Datasheet / COA / SDS

Catalog #	Availability	Size / Price	Qty
5357/50
5357/10

DC 260126 | CAS No. 346692-04-4 | Free Fatty Acid Receptor Antagonists

1 Image

Description: FFA1 (GPR40) antagonist

Chemical Name: N-(4-Butylphenyl)-4-fluorobenzenesulfonamide

Purity: ≥98%

View All Products for Free Fatty Acid Receptor Antagonists

Product Details

Supplemental Products

Reviews

Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

DC 260126 is a free fatty acid receptor 1 (FFA1/GPR40) antagonist. Inhibits FFA-induced increases in intracellular Ca²⁺ levels and suppresses palmitic acid potentiated glucose-stimulated insulin secretion in Min6 pancreatic β cells in vitro. Decreases serum insulin levels, improves insulin sensitivity and reduces the number of apoptotic pancreatic β cells in obese diabetic (db/db) rats.

Technical Data

M.Wt:

307.38

Formula:

C₁₆H₁₈FNO₂S

Solubility:

Soluble to 100 mM in DMSO and to 100 mM in ethanol

Purity:

≥98%

Storage:

Store at -20°C

CAS No:

346692-04-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

DC260126, a small-molecule antagonist of GPR40, improves Ins tolerance but not glucose tolerance in obese Zucker rats.
Zhang et al.
Biomed.Pharmacother., 2010;64:647
A novel class of antagonists for the FFAs receptor GPR40.
Hu et al.
Biochem.Biophys.Res.Comm., 2009;390:557
DC260126: a small-molecule antagonist of GPR40 that protects against pancreatic β-Cells dysfunction in db/db mice.
Sun et al.
PLoS ONE, 2013;8:e66744

Product Datasheets

COA view current batch

SDS

Reconstitution Calculator

Molarity Calculator

Reconstitution Calculator

Molarity Calculator

Mass

Concentration

Volume

M. Wt* g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

FAQs

No product specific FAQs exist for this product, however you may

View all Small Molecule FAQs

Reviews for DC 260126

There are currently no reviews for this product. Be the first to review DC 260126 and earn rewards!

Have you used DC 260126?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.