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dBRD9

Catalog #: 6606
3 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
6606/5
dBRD9 | CAS No. 2341840-98-8 | Active Degraders
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Description: Potent and selective BRD9 Degrader (PROTAC®)

Chemical Name: 2-[[[4-(1,2-Dihydro-2-methyl-1-oxo-2,7-naphthyridin-4-yl)-2-6-dimethoxyphenyl]methyl]methylamino]-N-[2-[2-[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]ethoxy]ethoxy]ethyl]acetamide dihydrochloride

Purity: ≥98%

Product Details
Citations (3)
Reviews
Biological Activity Technical Data Additional Information Background Product Datasheets Calculators

Biological Activity

dBRD9 is a potent and selective Degrader (PROTAC®) of BRD9 (IC50 = 56.6 nM in MOLM-13 cells). dBRD9 is composed of the BRD9 inhibitor BI 7273 conjugated to the cereblon E3 ligase ligand pomalidomide (Cat. No. 6302). Does not degrade BRD4 or BRD7 at concentrations up to 5 μM. Displays antiproliferative effects in human AML cell lines.

PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.

Technical Data

M.Wt:
856.75
Formula:
C40H45N7O10.2HCl
Solubility:
Soluble to 20 mM in water and to 50 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
2341840-98-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold under license from Dana-Farber Cancer Institute.

Background References

  1. Degradation of the BAF complex factor BRD9 by heterobifunctional ligands.
    Remillard et al.
    Angew.Chem.Int.Ed.Engl., 2017;56:5738

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Citations for dBRD9

The citations listed below are publications that use Tocris products. Selected citations for dBRD9 include:

3 Citations: Showing 1 - 3

  1. Engineered PROTAC-CID systems for mammalian inducible gene regulation
    Authors: Ma Et al.
    J Am Chem Soc  2023;145:1593
  2. BRD9 regulates interferon-stimulated genes during macrophage activation via cooperation with BET protein BRD4.
    Authors: Nasun Et al.
    Proc Natl Acad Sci U S A  2022;119
  3. A Genome-wide CRISPR Screen Reveals a Role for the Non-canonical Nucleosome-Remodeling BAF Complex in Foxp3 Expression and Regulatory T Cell Function
    Authors: Loo Et al.
    Immunity  2020;53:143

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