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dBRD9-A

Catalog #: 6943
1 Citation Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
6943/5
dBRD9-A | CAS No. 2170679-42-0 | Active Degraders
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Description: Potent BRD9 Degrader (PROTAC®)

Chemical Name: 2-((2,6-Dimethoxy-4-(2-methyl-1-oxo-1,2-dihydro-2,7-naphthyridin-4-yl)benzyl)(methyl)amino)-N-(8-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)octyl)acetamide

Purity: ≥98%

Product Details
Citations (1)
Reviews
Biological Activity Technical Data Additional Information Background Product Datasheets Calculators

Biological Activity

dBRD9-A is a potent BRD9 Degrader (PROTAC®). Selectively binds BRD9 and elicits near complete degradation of BRD9 at nanomolar concentrations. Inhibits growth of synovial sarcoma cells in vitro and tumor progression in a synovial sarcoma xenograft mouse model.

PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.

Technical Data

M.Wt:
779.88
Formula:
C42H49N7O8
Solubility:
Soluble to 100 mM in DMSO and to 10 mM in ethanol
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
2170679-42-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold under license from Dana-Farber Cancer Institute

Product Datasheets

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Citation for dBRD9-A

The citations listed below are publications that use Tocris products. Selected citations for dBRD9-A include:

1 Citation: Showing 1 - 1

  1. SMARCE1 deficiency generates a targetable mSWI/SNF dependency in clear cell meningioma.
    Authors: Nazar Et al.
    Nat Genet  2022;54:861-873

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