CZC 25146

Catalog #: 6071 Datasheet / COA / SDS

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CZC 25146 | CAS No. 1191911-26-8 | LRRK2 Inhibitors

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Description: Potent LRRK2 inhibitor

Chemical Name: N-[2-[[5-Fluoro-2-[[2-methoxy-4-(4-morpholinyl)phenyl]amino]-4-pyrimidinyl]amino]phenyl]methanesulfonamide

Purity: ≥98%

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Biological Activity

CZC 25146 is a potent LRRK2 inhibitor (IC₅₀ values are 4.76 and 6.87 nM for for wild-type and G2019S mutant forms of LRRK2, respectively). Also inhibits PLK4, GAK, TNK1, CAMKK2 and PIP4K2. Attenuates mutant LRRK2-induced injury of cultured rodent and human neurons. Cell permeable.

Technical Data

M.Wt:

488.54

Formula:

C₂₂H₂₅FN₆O₄S

Solubility:

Soluble to 100 mM in DMSO

Purity:

≥98%

Storage:

Store at -20°C

CAS No:

1191911-26-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

Chemoproteomics-based design of potent LRRK2-selective lead compounds that attenuate Parkinson's disease-related toxicity in human neurons.
Ramsden et al.
ACS Chem.Biol., 2011;6:1021

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