Cynomolgus Monkey ITGB2/CD18 (XP_005548577) VersaClone cDNA

Cynomolgus Monkey ITGB2/CD18 (XP_005548577) VersaClone cDNA Summary

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Background: Integrin beta 2/CD18

Integrins are transmembrane proteins that mediate interactions between adhesion molecules on adjacent cells and/or the extracellular matrix (ECM). Integrins have diverse roles in several biological processes including cell migration during development and wound healing, cell differentiation, and apoptosis. Their activities can also regulate the metastatic and invasive potential of tumor cells. They exist as heterodimers consisting of alpha and beta subunits. Some alpha and beta subunits exhibit specificity for one another and may be designated as a VLA (very late antigen) member. Heterodimers often preferentially bind certain cell adhesion molecules, or constituents of the ECM. Although they have no catalytic activity, integrins can be part of multimolecular signaling complexes known as focal adhesions.

Related Research Areas

• Actin Stress Fibers and Focal Adhesions During EMT
• Adhesion Molecules
• Adhesion Molecules in Angiogenesis
• Adhesion Molecules on VSMC
• Adhesive Interactions in Allergy and Asthma
• B Cell Chemotaxis, Migration, and Adhesion
• Dendritic Cell Adhesion and Migration
• Integrins and Associated Molecules
• Microglia Activation
• Microglia Homeostasis
• Myeloid Lineage Markers
• Platelet Activation Markers
• Regulatory T Cells (Tregs)
• T Cell Migration/Adhesion
• Uptake of Amyloid beta by Glia Cells