CYN 154806
Purity: ≥95%
Biological Activity
CYN 154806 is a potent and selective somatostatin sst2 receptor antagonist. pIC50 values are 8.58, 5.41, 6.07, 5.76 and 6.48 for human recombinant sst2, sst1, sst3, sst4 and sst5 receptors respectively.Technical Data
(Modifications: Phe-1 = Ac-(4-nitro)Phe, Cys-2 = D-Cys, Trp-4 = D-Trp, Tyr-8 = D-Tyr & C-terminal amide, Disulfide bridge: 2-7)
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Neurochemical characterisation of lamina II inhibitory interneurons that express GFP in the PrP-GFP mouse.
Iwagaki N, Garzillo F, Polgar E, Riddell J, Todd A
Mol Pain, 2013;9(0):56. -
Identification and characterization of novel somatostatin antagonists.
Bass et al.
Mol.Pharmacol., 1996;50:709 -
Selective somatostatin sst2 receptor blockade with the novel cyclic octapeptide, CYN-154806.
Feniuk et al.
Neuropharmacology, 2000;39:1443 -
Drug design at peptide receptors. Somatostatin receptor ligands.
Hannon et al.
J.Mol.Neurosci., 2002;18:15 -
Viability fingerprint of glioblastoma cell lines: roles of mitotic, proliferative, and epigenetic targets
D Lavogina, T Laasfeld, M Vardja, H Lust, J Jaal
Scientific Reports, 2021;11(1):20338.
Product Datasheets
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Citations for CYN 154806
The citations listed below are publications that use Tocris products. Selected citations for CYN 154806 include:
8 Citations: Showing 1 - 8
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Somatostatin 2 Receptors in the Spinal Cord Tonically Restrain Thermogenic, Cardiac and Other Sympathetic Outflows.
Authors: Bowman Et al.
Front Neurosci 2019;13:121
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Electrophysiological properties of human beta-cell lines EndoC-βH1 and -βH2 conform with human beta-cells.
Authors: Hastoy Et al.
Sci Rep 2018;8:16994
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Targeting Somatostatin Receptors By Functionalized Mesoporous Silica Nanoparticles - Are We Striking Home?.
Authors: Paramonov Et al.
Nanotheranostics 2018;2:320
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Somatostatin and Ins mediate glucose-inhibited glucagon secretion in the pancreatic α-cell by lowering cAMP.
Authors: Elliott Et al.
Am J Physiol Endocrinol Metab 2015;308:E130
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Neurochemical characterisation of lamina II inhibitory interneurons that express GFP in the PrP-GFP mouse.
Authors: Iwagaki Et al.
Mol Pain 2013;9:56
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Analog of somatostatin vapreotide exhibits biological effects in vitro via interaction with neurokinin-1 receptor.
Authors: Spitsin Et al.
J Leukoc Biol 2013;20:247
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5-HT(1A), SST(1), and SST(2) receptors mediate inhibitory postsynaptic potentials in the submucous plexus of the guinea pig ileum.
Authors: Foong Et al.
Neuroimmunomodulation 2010;298:G384
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Activation of submucosal 5-HT(3) receptors elicits a somatostatin-dependent inhibition of ion secretion in rat colon.
Authors: Yang Et al.
Br J Pharmacol 2010;159:1623
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