CYM 5541
Chemical Name: N,N-Dicyclohexyl-5-cyclopropyl-3-isoxazolecarboxamide
Purity: ≥97%
Biological Activity
CYM 5541 is a selective sphingosine-1-phosphate receptor 3 (S1P3) allosteric agonist (EC50 = 72-132 nM). Occupies a different space within the ligand binding pocket of S1P3 than S1P. Displays no activity at S1P1, S1P2, S1P4 and S1P5 receptors at concentrations up to 10 μM. Shows no significant activities in a profiling panel of 55 GPCRs, ion channels and transporters.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Novel selective allosteric and bitopic ligands for the S1P3 receptor.
Jo et al.
ACS Chem.Biol., 2012;7:1975
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Citations for CYM 5541
The citations listed below are publications that use Tocris products. Selected citations for CYM 5541 include:
6 Citations: Showing 1 - 6
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Two distinct trophectoderm lineage stem cells from human pluripotent stem cells.
Authors: Balaji M Et al.
J Biol Chem 2021;296:100386
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Utilizing Designed Receptors Exclusively Activated by Designer Drug Chemogenetic Tools to Identify Beneficial G Protein-Coupled Receptor Signaling for Fibrosis.
Authors: Tzu-Ming Et al.
J Pharmacol Exp Ther 2020;375:357-366
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Developmental potential of aneuploid human embryos cultured beyond implantation.
Authors: Antonio Et al.
Nat Commun 2020;11:3987
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Sphingosine 1-phosphate (S1P) reduces hepatocyte growth factor-induced migration of hepatocellular carcinoma cells via S1P receptor 2.
Authors: Matsushima-Nishiwaki Et al.
PLoS One 2018;13:e0209050
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The dual S1PR1/S1PR5 drug BAF312 (Siponimod) attenuates demyelination in organotypic slice cultures.
Authors: O'Sullivan Et al.
Nat Commun 2016;13:31
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Fingolimod induces neuroprotective factors in human astrocytes.
Authors: Hoffmann Et al.
J Neuroinflammation 2015;12:184
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