Home / Sphingosine-1-phosphate Receptor Agonists / CYM 5541

CYM 5541

Catalog #: 4897
6 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
4897/10
4897/50
CYM 5541 | CAS No. 945128-26-7 | Sphingosine-1-phosphate Receptor Agonists
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Description: Selective S1P3 receptor allosteric agonist

Chemical Name: N,N-Dicyclohexyl-5-cyclopropyl-3-isoxazolecarboxamide

Purity: ≥97%

Product Details
Citations (6)
Supplemental Products
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Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

CYM 5541 is a selective sphingosine-1-phosphate receptor 3 (S1P3) allosteric agonist (EC50 = 72-132 nM). Occupies a different space within the ligand binding pocket of S1P3 than S1P. Displays no activity at S1P1, S1P2, S1P4 and S1P5 receptors at concentrations up to 10 μM. Shows no significant activities in a profiling panel of 55 GPCRs, ion channels and transporters.

Technical Data

M.Wt:
316.44
Formula:
C19H28N2O2
Solubility:
Soluble to 100 mM in DMSO and to 50 mM in ethanol
Purity:
≥97%
Storage:
Store at +4°C
CAS No:
945128-26-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Novel selective allosteric and bitopic ligands for the S1P3 receptor.
    Jo et al.
    ACS Chem.Biol., 2012;7:1975

Product Datasheets

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Citations for CYM 5541

The citations listed below are publications that use Tocris products. Selected citations for CYM 5541 include:

6 Citations: Showing 1 - 6

  1. Two distinct trophectoderm lineage stem cells from human pluripotent stem cells.
    Authors: Balaji M Et al.
    J Biol Chem  2021;296:100386
  2. Utilizing Designed Receptors Exclusively Activated by Designer Drug Chemogenetic Tools to Identify Beneficial G Protein-Coupled Receptor Signaling for Fibrosis.
    Authors: Tzu-Ming Et al.
    J Pharmacol Exp Ther  2020;375:357-366
  3. Developmental potential of aneuploid human embryos cultured beyond implantation.
    Authors: Antonio Et al.
    Nat Commun  2020;11:3987
  4. Sphingosine 1-phosphate (S1P) reduces hepatocyte growth factor-induced migration of hepatocellular carcinoma cells via S1P receptor 2.
    Authors: Matsushima-Nishiwaki Et al.
    PLoS One  2018;13:e0209050
  5. The dual S1PR1/S1PR5 drug BAF312 (Siponimod) attenuates demyelination in organotypic slice cultures.
    Authors: O'Sullivan Et al.
    Nat Commun  2016;13:31
  6. Fingolimod induces neuroprotective factors in human astrocytes.
    Authors: Hoffmann Et al.
    J Neuroinflammation  2015;12:184

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