Cyanopindolol hemifumarate
Chemical Name: 4-[3-[tert-Butylamino]-2-hydroxypropoxy]-1H-indole-2-carbonitrile hemifumarate
Purity: ≥98%
Biological Activity
Cyanopindolol hemifumarate is a 5-HT1A/1B antagonist with roughly equal affinity at each receptor; also a β-adrenoceptor antagonist.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death.
Fox JT, Sakamuru S, Huang R
Proc. Natl. Acad. Sci. U.S.A., 2012;109(14):5423-8. -
Identity of presynaptic 5-hydroxytryptamine (5-HT) autoreceptors in the rat brain cortex with 5-HT1B binding sites.
Engel et al.
Naunyn Schmiedebergs Arch.Pharmacol., 1986;332:1 -
Atypical responses of rat ileum to pindolol, cyanopindolol and iodocyanopindolol.
Hoey et al.
Br.J.Pharmacol., 1996;117:712 -
Characterization of a 5-HT1B receptor on CHO cells: functional responses in the absence of radioligand binding.
Giles et al.
Br.J.Pharmacol., 1996;117:1119 -
Interaction of dihydroalprenolol and cyanopindolol with atypical β-adrenoceptors in guinea-pig ileum.
Blue et al.
Br.J.Pharmacol., 1989;96:246P
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Citations for Cyanopindolol hemifumarate
The citations listed below are publications that use Tocris products. Selected citations for Cyanopindolol hemifumarate include:
4 Citations: Showing 1 - 4
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Tryptophan hydroxylase 1 and 5-HT7 receptor preferentially expressed in triple-negative breast cancer promote cancer progression through autocrine serotonin signaling.
Authors: Gautam Et al.
Mol Cancer 2016;15:75
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Coupling of β2-adrenoceptors to XLαs and Gαs: a new insight into ligand-induced G protein activation.
Authors: Kaya Et al.
J Pharmacol Exp Ther 2009;329:350
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ALpha1-adrenoceptor antagonist properties of CGP 12177A and other beta-adrenoceptor ligands: evidence against beta(3)- or atypical beta-adrenoceptors in rat aorta.
Authors: Brahmadevara Et al.
Br J Pharmacol 2004;142:781
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Involvement of 5-HT1B receptors in collar-induced hypersensitivity to 5-hydroxytryptamine of the rabbit carotid artery.
Authors: Geerts Et al.
Br J Pharmacol 1999;127:1327
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