Home / Protein Tyrosine Phosphatase Inhibitors / CX08005

CX08005

Catalog #: 6144 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
6144/25
6144/5
CX08005 | CAS No. 1256341-22-6 | Protein Tyrosine Phosphatase Inhibitors
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Description: Competitive PTP1B inhibitor

Chemical Name: 2-[[[2-(Tetradecyl)phenyl]amino]carbonyl]benzoic acid

Purity: ≥98%

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Biological Activity

CX08005 is a competitive PTP1B inhibitor (IC50 = 0.781 μM). Binds catalytic P-loop of enzyme. Improves insulin sensitivity in obese mice in the glucose tolerance test and the homeostasis model assessment of insulin resistance index (HOMA-IR). Enhances insulin-induced glucose uptake in adipocytes and myotubes in vitro. Exhibits some selectivity for PTP1B over other protein tyrosine phosphatases, except TCPTP.

Technical Data

M.Wt:
453.61
Formula:
C28H39N04
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
1256341-22-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. A novel protein tyrosine phosphatase 1B inhibitor with therapeutic potential for Ins resistance.
    Zhang et al.
    Br.J.Pharmacol., 2016;173:1939

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