CRT 0066854 hydrochloride
Chemical Name: (2S)-3-Phenyl-N1-[5,6,7,8-tetrahydro-2-(4-pyridinyl)[1]benzothieno[2,3-d]pyrimidin-4-yl]-1,2-propanediamine dihydrochloride
Purity: ≥95%
Biological Activity
CRT 0066854 hydrochloride is a protein kinase C (PKC) inhibitor. Inhibits PKCι and PKCζ (IC50 values are 132 and 639 nM, respectively). Restores polarized morphogenesis in oncogene expressing MDCK cells, decreases colony formation in HeLa cells and inhibits lethal giant larvae 2 (LLGL2) phosphorylation.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Regulation of polarized morphogenesis by protein kinase C iota in oncogenic epithelial spheroids.
Linch et al.
Carcinogenesis, 2014;35:396 -
Adenosine-binding motif mimicry and cellular effects of a thieno[2,3-d]pyrimidine-based chemical inhibitor of atypical protein kinase C isoenzymes.
Kjaer et al.
Biochem.J., 2013;451:329
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Citation for CRT 0066854 hydrochloride
The citations listed below are publications that use Tocris products. Selected citations for CRT 0066854 hydrochloride include:
1 Citation: Showing 1 - 1
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Protein kinase Cι and SRC signaling define reciprocally related subgroups of glioblastoma with distinct therapeutic vulnerabilities.
Authors: Jann N Et al.
Cell Rep 2021;37:110054
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