Cortistatin 14

Catalog # Availability Size / Price Qty
3374/1
Cortistatin 14
1 Image
Description: Endogenous neuropeptide; binds sst1 - sst5, ghrelin receptor and MRGPRX2

Purity: ≥95%

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Biological Activity

Cortistatin 14 is an endogenous neuropeptide, mainly expressed in the cortex and hippocampus, that has structural and functional similarities to somatostatin-14. Cortistatin 14 displays potency at all somatostatin receptors (sst1 - sst5) and prevents somatostatin-14 binding (IC50 values are 0.09, 0.2, 0.3, 0.3 and 5 nM at sst2, sst4, sst3, sst5 and sst1 receptors, respectively). Also a potent MRGPRX2 agonist (EC50 = 25 nM in HEK293 cells) and binds to the growth hormone secretagog receptor (GHS-R1a). Exhibits neuronal depressant and sleep-modulating properties in vivo.

Technical Data

M.Wt:
1721.03
Formula:
C81H113N19O19S2
Sequence:
PCKNFFWKTFSSCK

(Modifications: Disulfide bridge: 2-13)

Solubility:
Soluble to 0.70 mg/ml in water
Purity:
≥95%
Storage:
Store at -20°C
CAS No:
193829-96-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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