Colivelin
Purity: ≥95%
Biological Activity
Colivelin is a neuroprotective peptide and activator of STAT3. Protects neurons against the neurotoxic effects of amyloid β-peptide (1-43) at a concentration of 100 fM in vitro. Suppresses neuronal death by activating STAT3 in vitro; upregulates cholinergic transmission and ameliorates memory impairment in Alzheimer's disease (AD) models. Also prevents alcohol-induced apoptosis in a fetal mouse model. Brain penetrant.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Tyrosine kinase c-Abl regulates the survival of plasma cells
YF Li, S Xu, Y Huang, X Ou, KP Lam
Sci Rep, 2017;7(0):40133. -
A novel peptide, colivelin, prevents alcohol-induced apoptosis in fetal brain of C57BL/6 mice: signaling pathway investigations.
Sari et al.
Neuroscience, 2009;164:1653 -
Nasal colivelin treatment ameliorates memory impairment related to Alzheimer's disease.
Yamada et al.
Neuropsychopharmacology, 2008;33:2020 -
Development of a femtomolar-acting humanin derivative named colivelin by attaching activity-dependent neurotrophic factor to its N terminus: characterization of colivelin-mediated neuroprotection against Alzheimer's disease-relevant insults in vitro a
Chiba et al.
J.Neurosci., 2005;25:10252
Product Datasheets
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Citations for Colivelin
The citations listed below are publications that use Tocris products. Selected citations for Colivelin include:
3 Citations: Showing 1 - 3
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TAM Family Receptor Kinase Inhibition Reverses MDSC-Mediated Suppression and Augments Anti-PD-1 Therapy in Melanoma.
Authors: Xiaodong Et al.
Cancer Immunol Res 2019;7:1672-1686
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The ameliorative effect of fluoxetine on neuroinflammation induced by sleep deprivation.
Authors: Li Et al.
J Neurochem 2017;
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Long-term heart transplant survival by targeting the ionotropic purinergic receptor P2X7.
Authors: Vergani Et al.
J Cell Biol 2013;127:463
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