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CNQX disodium salt

Catalog #: 1045
36 Citations Datasheet / COA / SDS
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CNQX disodium salt | CAS No. 479347-85-8 | AMPA Receptor Antagonists
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Description: Potent non-NMDA iGluR antagonist; more water soluble form of CNQX (Cat. No. 0190)

Chemical Name: 6-Cyano-7-nitroquinoxaline-2,3-dione disodium

Purity: ≥99%

Product Details
Citations (36)
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Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

CNQX disodium salt is a more water-soluble disodium salt of the AMPA and kainate antagonist CNQX (Cat. No. 0190), which is an AMPA and kainate receptor antagonist (IC50 values are 0.3 μM, 1.5 μM for AMPA and kainate receptors, respectively). CNQX is also an antagonist at the glycine modulatory site on the NMDA receptor complex (IC50 = 25 μM). CNQX can be used to isolate GABAA receptor mediated spontaneous inhibitory postsynaptic currents and antagonizes non-NMDA receptor-mediated responses in cultured cerebellar granule cells. CNQX shows neuroprotective effects in models of ischemia and inhibits seizure-like activity in hippocampal neurons.

Technical Data

M.Wt:
276.12
Formula:
C9H2N4O4Na2
Solubility:
Soluble to 10 mM in water
Purity:
≥99%
Storage:
Desiccate at RT
CAS No:
479347-85-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Neuromuscular NMDA Receptors Modulate Developmental Synapse Elimination
    KE Personius, BS Slusher, SB Udin
    J. Neurosci, 2016;36(34):8783-9.
  2. Aberrant neuronal activity-induced signaling and gene expression in a mouse model of RASopathy
    F Altmüller, S Pothula, A Annamneedi, S Nakhei-Rad, C Montenegro, E Pina-Ferná, C Marini, M Santos, D Schanze, D Montag, MR Ahmadian, O Stork, M Zenker, A Fejtova
    PLoS Genet, 2017;13(3):e1006684.
  3. High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death.
    Fox JT, Sakamuru S, Huang R
    Proc. Natl. Acad. Sci. U.S.A., 2012;109(14):5423-8.
  4. Input-specific control of reward and aversion in the ventral tegmental area.
    Lammel S, Lim B, Ran C, Huang K, Betley M, Tye K, Deisseroth K, Malenka R
    Nature, 2012;491(7423):212-7.
  5. Quinoxalinediones: potent competitive non-NMDA glutamate receptor antagonists.
    Honore et al.
    Science, 1988;241:701
  6. Structure-activity relationships in the development of excitatory amino acid receptor agonists and competitive antagonists.
    Watkins et al.
    TiPS, 1990;11:25
  7. Antagonism of synaptic potentials in ventral horn neurones by 6-cyano-7-nitroquinoxaline-2,3-dione: a study in the rat spinal cord in vitro.
    King et al.
    Br.J.Pharmacol., 1992;107:375
  8. Effect of 6-cyano-2,3-dihydroxy-7-nitro-quinoxaline (CNQX) on dorsal root-, NMDA-, kainate and quisqualate-mediated depolarization of rat motoneurones in vitro.
    Long et al.
    Br.J.Pharmacol., 1990;100:850
  9. Type I Interferon Receptor Signaling in Astrocytes Regulates Hippocampal Synaptic Plasticity and Cognitive Function of the Healthy CNS
    S Hosseini, K Michaelsen, G Grigoryan, C Chhatbar, U Kalinke, M Korte
    Cell Rep, 2020;31(7):107666.

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Citations for CNQX disodium salt

The citations listed below are publications that use Tocris products. Selected citations for CNQX disodium salt include:

36 Citations: Showing 1 - 10

  1. Chronic postnatal chemogenetic activation of forebrain excitatory neurons evokes persistent changes in mood behavior
    Authors: Pati Et al.
    Elife  2020;9
  2. Nucleus Accumbens Tac1-Expressing Neurons Mediate Stress-Induced Anhedonia-like Behavior in Mice.
    Authors: He Et al.
    Cell Rep  2020;33
  3. Functional Dissection of Basal Ganglia Inhibitory Inputs onto Substantia Nigra Dopaminergic Neurons.
    Authors: Evans Et al.
    Cell Rep  2020;32
  4. KCC2-Mediated Cl- Extrusion Modulates Spontaneous Hippocampal Network Events in Perinatal Rats and Mice.
    Authors: Spoljaric Et al.
    Cell Rep  2019;26:1073
  5. HIV gp120 upregulates tonic inhibition through α5-containing GABAARs.
    Authors: Green and Thayer Et al.
    Neuropharmacology  2019;149:161
  6. Functional Coupling of Cav2.3 and BK Potassium Channels Regulates Action Potential Repolarization and Short-Term Plasticity in the Mouse Hippocampus.
    Authors: Gutzmann Et al.
    Front Cell Neurosci  2019;13:27
  7. Mitochondrial Regulation of the Hippocampal Firing Rate Set Point and Seizure Susceptibility.
    Authors: Styr Et al.
    Neuron  2019;102:1009
  8. Pathway-specific alterations of cortico-amygdala transmission in an arthritis pain model.
    Authors: Kiritoshi and Neugebauer
    ACS Chem Neurosci  2018;9:2252
  9. A Distance-Dependent Distribution of Presynaptic Boutons Tunes Frequency-Dependent Dendritic Integration.
    Authors: Grillo Et al.
    Neuron  2018;99:275
  10. A circuit from hippocampal CA2 to lateral septum disinhibits social aggression.
    Authors: Leroy Et al.
    Nature  2018;564:213
  11. Cerebrospinal Fluid-Contacting Neurons Sense pH Changes and Motion in the Hypothalamus.
    Authors: Jalalvand Et al.
    J Neurosci  2018;38:7713
  12. A role for proteolytic regulation of δ-catenin in remodeling a subpopulation of dendritic spines in the rodent brain.
    Authors: Yuan Et al.
    J Biol Chem  2018;293:11625
  13. Subcellular Localization and Activity of TRPM4 in Medial Prefrontal Cortex Layer 2/3.
    Authors: Riquelme Et al.
    Front Cell Neurosci  2018;12:12
  14. Initiation of Behavioral Response to Antidepressants by Cholecystokinin Neurons of the Dentate Gyrus.
    Authors: Medrihan Et al.
    Neuron  2017;95:564
  15. Spatiotemporal Regulation of Synaptic Vesicle Fusion Sites in Central Synapses.
    Authors: Maschi and Klyachko
    Neuron  2017;94:65
  16. Cortical cells reveal APP as a new player in the regulation of GABAergic neurotransmission.
    Authors: Doshina Et al.
    Sci Rep  2017;7:370
  17. Speed and segmentation control mechanisms characterized in rhythmically-active circuits created from spinal neurons produced from genetically-tagged embryonic stem cells.
    Authors: Sternfeld Et al.
    Elife  2017;6
  18. Serotonin enhances excitability and gamma frequency temporal integration in mouse prefrontal fast-spiking interneurons.
    Authors: Athilingam Et al.
    Elife  2017;6
  19. Comparison of NMDA and AMPA Channel Expression and Function between Embryonic and Adult Neurons Utilizing Microelectrode Array Systems.
    Authors: Edwards Et al.
    ACS Biomater Sci Eng  2017;3:3525
  20. A New Promoter Allows Optogenetic Vision Restoration with Enhanced Sensitivity in Macaque Retina.
    Authors: Chaffiol Et al.
    Mol Ther  2017;25:2546
  21. Transcriptional Architecture of Synaptic Communication Delineates GABAergic Neuron Identity.
    Authors: Paul Et al.
    Cell  2017;171:522
  22. Targeted Intron Retention and Excision for Rapid Gene Regulation in Response to Neuronal Activity.
    Authors: Mauger Et al.
    Neuron  2016;92:1266
  23. Differential Somatic Ca2+ Channel Profile in Midbrain DArgic Neurons
    Authors: Philippart Et al.
    The Journal of Neuroscience  2016;6:7234
  24. Dynamic Partitioning of Synaptic Vesicle Pools by the SNARE-Binding Protein Tomosyn.
    Authors: Cazares Et al.
    J Neurosci  2016;36:11208
  25. A Cortical Circuit for Sexually Dimorphic Oxytocin-Dependent Anxiety Behaviors.
    Authors: Li Et al.
    Cell  2016;167:60
  26. Vasoactive Intestinal Peptide Excites GnRH Neurons in Male and Female Mice.
    Authors: Piet Et al.
    Endocrinology.  2016;157:3621
  27. Interaction of electrically evoked activity with intrinsic dynamics of cultured cortical networks with and without functional fast GABAergic synaptic transmission.
    Authors: Baltz and Voigt
    Front Cell Neurosci  2015;9:272
  28. Functional plasticity of GAT-3 in avian Müller cells is regulated by neurons via a glutamatergic input.
    Authors: Schitine Et al.
    J Neurosci  2015;82:42
  29. Systems reconsolidation reveals a selective role for the anterior cingulate cortex in generalized contextual fear memory expression.
    Authors: Einarsson Et al.
    J Endocrinol  2015;40:480
  30. Extracellular glutamate exposure facilitates group I mGluR-mediated epileptogenesis in the hippocampus.
    Authors: Zhao Et al.
    Neuropsychopharmacology  2015;35:308
  31. Long-term potentiation can be induced in the CA1 region of hippocampus in the absence of αCaMKII T286-autophosphorylation.
    Authors: Villers Et al.
    Learn Mem  2014;21:616
  32. Paraneoplastic CDR2 and CDR2L antibodies affect Purkinje cell calcium homeostasis.
    Authors: Schubert Et al.
    Acta Neuropathol  2014;128:835
  33. Tissue engineering the monosynaptic circuit of the stretch reflex arc with co-culture of embryonic motoneurons and proprioceptive sensory neurons.
    Authors: Guo Et al.
    Biomaterials  2012;33:5723
  34. Neuregulin directly decreases voltage-gated sodium current in hippocampal ErbB4-expressing interneurons.
    Authors: Janssen Et al.
    J Neurosci  2012;32:13889
  35. Pharmacological evidence that D-aspartate activates a current distinct from ionotropic glutamate receptor currents in Aplysia californica.
    Authors: Carlson Et al.
    Brain Behav  2012;2:391
  36. The serine protease plasmin cleaves the amino-terminal domain of the NR2A subunit to relieve zinc inhibition of the N-MthD.-aspartate receptors.
    Authors: Yuan Et al.
    J Biol Chem  2009;284:12862

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