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CLP 257

Catalog #: 5242
1 Citation Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
5242/50
5242/10
CLP 257 | CAS No. 1181081-71-9 | KCC2 Activators
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Description: Selective KCC2 activator

Chemical Name: (5Z)-5-[(4-Fluoro-2-hydroxyphenyl)methylene]-2-(tetrahydro-1-(2H)-pyridazinyl)-4(5H)-thiazolone

Purity: ≥98%

Product Details
Citations (1)
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Biological Activity

CLP 257 is a selective KCC2 K+-Cl- cotransporter activator (EC50 = 616 nM). Exhibits selectivity for KCC2 over other KCC family members, NKCC1 and GABAA receptors, as well as 55 other receptors. Enhances Cl- transport and increases KCC2 plasma membrane expression in spinal slices with reduced KCC2 function. Alleviates hypersensitivity in rats with peripheral nerve injury.

Technical Data

M.Wt:
307.34
Formula:
C14H14FN3O2S
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
1181081-71-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Chloride extrusion enhancers as novel therapeutics for neurological diseases.
    Gagnon et al.
    Nat.Med., 2013;19:1524

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Citation for CLP 257

The citations listed below are publications that use Tocris products. Selected citations for CLP 257 include:

1 Citation: Showing 1 - 1

  1. Diminished KCC2 confounds synapse specificity of LTP during senescence.
    Authors: Ferando Et al.
    Nat Neurosci  2016;19:1197

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