Clocinnamox mesylate
Chemical Name: 14β-(p-Chlorocinnamoylamino)-7,8-dihydro-N-cyclopropylmethylmorphinone mesylate
Purity: ≥98%
Biological Activity
Clocinnamox mesylate is a systemically active, irreversible μ-opioid receptor antagonist (apparent Ki values are 0.7, 1.9 and 5.7 nM for mouse μ, δ and κ receptors respectively).Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Irreversible opioid antagonist effects of clocinnamox on opioid analgesia and mu receptor binding in mice.
Burke et al.
J.Pharmacol.Exp.Ther., 1994;271:715 -
Mechanism of clocinnamox blockade of opioid receptors: evidence from in vitro and ex vivo binding and behavioural assays.
Zernig et al.
J.Pharmacol.Exp.Ther., 1996;279:23 -
Methocinnamox is a potent, long-lasting, and selective antagonist of morphine-mediated antinociception in the mouse: comparison with clocinnamox, β-funaltrexamine, and β-chlornaltrexamine.
Broadbear et al.
J.Pharmacol.Exp.Ther., 2000;294:933 -
Very long-acting narcotic antagonists. The 14β-p-substituted cinnamoylaminomorphinones and their partial mu agonist codeinone relatives.
Aceto et al.
Arzneimittelforschung, 1989;39:570
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Citation for Clocinnamox mesylate
The citations listed below are publications that use Tocris products. Selected citations for Clocinnamox mesylate include:
1 Citation: Showing 1 - 1
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The analgesic efficacy of fentanyl: relationship to tolerance and mu-opioid receptor regulation.
Authors: Sirohi Et al.
Pharmacol Biochem Behav 2008;91:115
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