Clemastine fumarate

Catalog #: 1453
2 Citations Datasheet / COA / SDS

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Clemastine fumarate | CAS No. 14976-57-9 | Histamine H1 Receptor Antagonists

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Description: H1 antagonist

Chemical Name: (2R)-2-[2-[(1R)-1-(4-Chlorophenylethoxy]ethyl]-1-methyl-2-pyrrolidine fumarate

Purity: ≥98%

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Product Details

Citations (2)

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Biological Activity

Clemastine fumarate is a h₁-receptor antagonist. Enhances differentiation of oligodendrocyte progenitor cells into myelin basic protein-positive oligodendrocytes in vitro and promotes remyelination in vivo. Also displays antimuscarinic properties. Clinically-used antihistamine.

Technical Data

M.Wt:

459.97

Formula:

C₂₁H₂₆ClNO.C₄H₄O₄

Solubility:

Soluble to 20 mM in DMSO

Purity:

≥98%

Storage:

Store at RT

CAS No:

14976-57-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

Multimodal Enhancement of Remyelination by Exercise with a Pivotal Role for Oligodendroglial PGC1?
SK Jensen, NJ Michaels, S Ilyntskyy, MB Keough, O Kovalchuk, VW Yong
Cell Rep, 2018;24(12):3167-3179.
Histamine1-histamine2 antagonism: effect of combined clemastine and cimetidine pretreatment on allergen and histamine-induced reactions of the guinea pig lung in vivo and in vitro.
Dorsch et al.
Agents Actions, 1982;12:113
Modulation of histamine-induced bronchoconstriction with inhaled, oral, and intravenous clemastine in normal and asthmatic subjects.
Hartmann et al.
Thorax, 1981;36:737
Effect of histamine and histamine antagonists on natural and antibody-dependent cellular cytotoxicity of human lymphocytes in vitro.
Nair and Schwartz
Cell.Immunol., 1983;81:45

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Citations for Clemastine fumarate

The citations listed below are publications that use Tocris products. Selected citations for Clemastine fumarate include:

2 Citations: Showing 1 - 2

Elucidation and Pharmacological Targeting of Novel Molecular Drivers of Follicular Lymphoma Progression.
Authors: Bisikirska Et al.
Cancer Res 2016;76:664
Clemastine potentiates the human P2X7 receptor by sensitizing it to lower ATP concentrations.
Authors: Nörenberg Et al.
J Biol Chem 2011;286:11067

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