Cilostamide

Biological Activity

Technical Data

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

1. High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death.
   Fox JT, Sakamuru S, Huang R
   Proc. Natl. Acad. Sci. U.S.A., 2012;109(14):5423-8.
2. beta-Adrenergic cAMP signals are predominantly regulated by phosphodiesterase type 4 in cultured adult rat aortic smooth muscle cells.
   Zhai K, Hubert F, Nicolas V, Ji G, Fischmeister R, Leblais V
   PLoS ONE, 2012;7(10):e47826.
3. Olanzapine: preclinical and clinical profiles of a novel antipsychotic agent.
   Tollefson and Taylor
   CNS Drug Reviews, 2000;6:303
4. Selective inhibitor of platelet cyclic adenosine monophosphate phosphodiesterase, cilostamide, inhibits platelet aggregation.
   Hidaki et al.
   J.Pharmacol.Exp.Ther., 1979;211:26
5. Potent effects of novel anti-platelet aggregatory cilostamide analogues on recombinant cyclic nucleotide phosphodiesterase isozyme activity.
   Sudo et al.
   Biochem.Pharmacol., 2000;59:347
6. Isozyme-selective phosphodiesterase inhibitors as antiasthmatic agents.
   Christensen and Torphy
   Annu.Rep.Med.Chem., 1994;29:185

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