Chicago Sky Blue 6B
Discontinued Product
Chemical Name: 6,6'-[(3,3-Dimethoxy[1,1'-biphenyl]-4,4'-diyl)bis(azo)]bis[4-amino-5-hydroxy-1,3-napthalenedisulphonic acid] tetrasodium salt
Biological Activity
Chicago Sky Blue 6B is a potent inhibitor of L-glutamate uptake into synaptic vesicles. Allosterically inhibits macrophage migration inhibitory factor (MIF) (IC50 = 0.81 μM); inhibits MIF proinflammatory activity. Also dye used as counterstain in histochemistry.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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A novel allosteric inhibitor of macrophage migration inhibitory factor (MIF).
Bai et al.
J.Biol.Chem., 2012;287:30653 -
Uptake of L-glutamate into rat brain synaptic vesicles: effect of inhibitors that bind specifically to the glutamate transport.
Roseth et al.
J.Neurochem., 1995;65:96 -
Inhibitors of amino acid uptake into vesicles.
Fonnum et al.
J.Neurochem., 1994;63:Suppl. 1 S49A
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Citation for Chicago Sky Blue 6B
The citations listed below are publications that use Tocris products. Selected citations for Chicago Sky Blue 6B include:
1 Citation: Showing 1 - 1
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A novel allosteric inhibitor of macrophage migration inhibitory factor (MIF).
Authors: Bai Et al.
J Biol Chem 2012;287:30653
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