CGS 12066B dimaleate

Catalog #: 0638
3 Citations Datasheet / COA / SDS

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0638/10
0638/50

CGS 12066B dimaleate | CAS No. 109028-10-6 | 5-HT1B Receptor Agonists

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Description: 5-HT1B agonist

Chemical Name: 7-Trifluoromethyl-4-(4-methyl-1-piperazinyl)pyrrolo[1,2-a]-quinoxaline dimaleate

Purity: ≥98%

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Product Details

Citations (3)

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Biological Activity

CGS 12066B dimaleate is a 5-HT_1B full agonist, 10-fold selective over 5-HT_1A and 1000-fold selective over 5-HT_2C receptors. Centrally active following systemic administration.

Technical Data

M.Wt:

566.49

Formula:

C₁₇H₁₇F₃N₄.2C₄H₄O₄

Solubility:

Soluble to 5 mM in water and to 40 mM in DMSO

Purity:

≥98%

Storage:

Store at RT

CAS No:

109028-10-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

Serotonin (5-HT) activation of immortalized hypothalamic neuronal cells through the 5-HT1B serotonin receptor.
Tung S, Hardy A, Wheeler M, Belsham D
Endocrinology, 2012;153(10):4862-73.
Biochemical and pharmacological characterization of CGS 12066B, a selective serotonin-1B agonist.
Neale et al.
Eur.J.Pharmacol., 1987;136:1
Effect of 5-HT_1B receptor ligands on self-administration of ethanol in an operant procedure in rats.
Tomkins and O'Neill
Pharmacol.Biochem.Behav., 2000;66:129
Interaction of arylpiperazines with 5-HT_1A, 5-HT_1B, 5-HT_1C and 5-HT_1D receptors: do discriminatory 5-HT_1B receptor ligands exist?
Schoeffter and Hoyer
Naunyn Schmiedebergs Arch.Pharmacol., 1989;339:675

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Citations for CGS 12066B dimaleate

The citations listed below are publications that use Tocris products. Selected citations for CGS 12066B dimaleate include:

3 Citations: Showing 1 - 3

Functional characterization of 5-HT_1A and 5-HT_1B serotonin receptor signaling through G-protein-activated inwardly rectifying K⁺ channels in a fluorescence-based membrane potential assay.
Authors: Gadgaard & Jensen
Biochem Pharmcol 2020;175
Lasting neurobehavioral abnormalities in rats after neonatal activation of serotonin 1A and 1B receptors: possible mechanisms for serotonin dysfunction in autistic spectrum disorders.
Authors: Khatri Et al.
Psychopharmacology (Berl) 2014;231:1191
Evidence that the deficit in sexual behavior in adult rats neonatally exposed to cital. is a consequence of 5-HT1 receptor stimulation during development.
Authors: Maciag Et al.
Brain Res 2006;1125:171

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