CGP 60474
Chemical Name: 3-[[4-[2-[(3-Chlorophenyl)amino]-4-pyrimidinyl]-2-pyridinyl]amino]-1-propanol
Purity: ≥98%
Biological Activity
CGP 60474 is a potent cyclin-dependent kinase (cdk) inhibitor (reported IC50 values are 3 - 80, 9.5, 13, 17 - 60, 200 and 220 nM for cdk2, cdk5, cdk9, cdk1, cdk4 and cdk7, respectively). Also inhibits PKCα in the low micromolar range. Displays reversible G1/S cell cycle arrest in U2-OS cells.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Novel and efficient access to phenylamino-pyrimidine type protein kinase C inhibitors utilizing a Negishi cross-coupling strategy.
Stanetty et al.
J.Org.Chem., 2005;70:5215 -
Cyclin-dependent kinase inhibitors: useful targets in cell cycle regulation.
Sielecki et al.
J.Med.Chem., 2000;43:1 -
How selective are pharmacological inhibitors of cell-cycle-regulating cyclin-dependent kinases?
Jorda et al.
J.Med.Chem., 2018;61:9105
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Citation for CGP 60474
The citations listed below are publications that use Tocris products. Selected citations for CGP 60474 include:
1 Citation: Showing 1 - 1
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How selective are pharmacological inhibitors of cell-cycle-regulating cyclin-dependent kinases?
Authors: Jorda Et al.
J.Med.Chem. 2018;61:9105
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