Ceramide

Biological Activity

Technical Data

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

1. High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death.
   Fox JT, Sakamuru S, Huang R
   Proc. Natl. Acad. Sci. U.S.A., 2012;109(14):5423-8.
2. Sphingosine regulates the NLRP3-inflammasome and IL-1beta release from macrophages.
   Luheshi NM, Giles JA, Lopez-Castejon G, Brough D
   Eur. J. Immunol., 2011;42(3):716-25.
3. Ceramide stimulates a cytosolic protein phosphatase.
   Dobowsky and Hannun
   J.Biol.Chem., 1992;267:5048
4. Identification of sphingomyelin turnover as an effector mechanism for the action of tumor necrosis factor α and γ-IF..
   Kim et al.
   J.Biol.Chem., 1991;266:484
5. Ceramide mediates the apoptotic response of WEHI 231 cells to anti-immunoglobulin, corticosteroids and irradiation.
   Quintans et al.
   Biochem.Biophys.Res.Commun., 1994;202:710
6. Ceramide selectively decreases tau levels in differentiated PC12 cells through modulation of calpain I.
   Xie and Johnson
   J.Neurochem., 1997;69:1020

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