CELT-133
Purity: ≥95%
Biological Activity
CELT-133 is a selective hα1A adrenergic receptor fluorescent antagonist. It shows full selectivity for α1A over α2A (Ki= 5 nM and 15% of displacement at 1 μM respectively in radioligand binding assay). CELT-133 binds equally to all subtypes of α1 adrenergic receptor. Excitation and emission maxima (λ) are 560 and 571 nm, respectively. Wavelengths are compatible with use as an acceptor dye in TR-FRET assays, together with the CoraFluor™ 1 (Cat. No. 7920) TR-FRET donor.Add 76 μL of assay buffer containing 1% of DMSO to obtain a 100 μM stock solution, and use 250 nM as a working concentration.
Optical Data for CELT-133
| Emission Color | Yellow |
|---|---|
| λabs | 560 nm |
| λem | 571 nm |
| Application | Fluorescence polarization, Confocal microscopy, High content screening |
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Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Additional Information
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