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Caspase-3 Inhibitor Z-DEVD-FMK

Catalog #: FMK004
78 Citations Datasheet / COA / SDS
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FMK004
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Citations (78)
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Caspase-3 Inhibitor Z-DEVD-FMK Summary

 

Key Benefits

Cell permeable fluoromethyl ketone (FMK)-derivatized peptides act as effective irreversible Caspase inhibitors with no cytotoxic effects and, therefore, are useful tools for studying Caspase activity.

Specifications

Source
N/A
Shipping Conditions
The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
Storage
Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.
Species
Multi-Species

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Background: Caspase-3

Caspases are a family of cytosolic aspartate-specific cysteine proteases involved in the initiation and execution of apoptosis. They are expressed as latent zymogens and are activated by an autoproteolytic mechanism or by processing by other proteases (frequently other caspases). Human caspases can be subdivided into three functional groups: cytokine activation (caspase-1, -4, -5, and -13), apoptosis initiation (caspase-2, -8, -9, -and -10), and apoptosis execution (caspase-3, -6, and -7).

Caspases are regulated by a variety of stimili, including APAF1, CFLAR/FLIP, NOL3/ARC, and members of the inhibitor of apoptosis (IAP) family such as BIRC1/NAIP, BIRC2/cIAP-1, BIRC3/cIAP-2, BIRC4/XIAP, BIRC5/Survivin, and BIRC7/Livin. IAP activity is modulated by DIABLO/SMAC or PRSS25/HTRA2/Omi. Cell-permeable and irreversible peptide inhibitors are also available for different caspases.

Entrez Gene IDs
836 (Human); 12367 (Mouse)
Alternate Names
Apopain; apoptosis-related cysteine protease; CASP3; CASP-3; caspase 3, apoptosis-related cysteine peptidase; Caspase3; Caspase-3; CPP32; CPP-32; CPP32B; CPP32SREBP cleavage activity 1; Cysteine protease CPP32; EC 3.4.22; EC 3.4.22.56; LICE-1; PARP cleavage protease; procaspase3; Protein Yama; SCA-1; YAMA

Citations for Caspase-3 Inhibitor Z-DEVD-FMK

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

78 Citations: Showing 1 - 10
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  1. Autism risk gene Cul3 alters neuronal morphology via caspase-3 activity in mouse hippocampal neurons
    Authors: Xia, QQ;Singh, A;Wang, J;Xuan, ZX;Singer, JD;Powell, CM;
    Frontiers in cellular neuroscience  2024-05-09
  2. Caloric restriction leads to druggable LSD1-dependent cancer stem cells expansion
    Authors: Pallavi, R;Gatti, E;Durfort, T;Stendardo, M;Ravasio, R;Leonardi, T;Falvo, P;Duso, BA;Punzi, S;Xieraili, A;Polazzi, A;Verrelli, D;Trastulli, D;Ronzoni, S;Frascolla, S;Perticari, G;Elgendy, M;Varasi, M;Colombo, E;Giorgio, M;Lanfrancone, L;Minucci, S;Mazzarella, L;Pelicci, PG;
    Nature communications  2024-01-27
  3. Proteome integral solubility alteration high-throughput proteomics assay identifies Collectin-12 as a non-apoptotic microglial caspase-3 substrate
    Authors: K Grabert, P Engskog-Vl, M Škandík, G Vazquez-Ca, AN Murgoci, L Keane, M Gaetani, B Joseph, M Cheray
    Cell Death & Disease, 2023-03-11;14(3):192.  2023-03-11
  4. Organoid-on-a-chip model of human ARPKD reveals mechanosensing pathomechanisms for drug discovery
    Authors: K Hiratsuka, T Miyoshi, KT Kroll, NR Gupta, MT Valerius, T Ferrante, M Yamashita, JA Lewis, R Morizane
    Science Advances, 2022-09-21;8(38):eabq0866.  2022-09-21
  5. Autolysosomes and caspase-3 control the biogenesis and release of immunogenic apoptotic exosomes
    Authors: D Beillevair, F Migneault, J Turgeon, D Gingras, AK Rimbaud, G Marcoux, C Spino, N Thibodeau, E Bonneil, P Thibault, É Boilard, M Dieudé, MJ Hébert
    Cell Death & Disease, 2022-02-11;13(2):145.  2022-02-11
  6. Streptococcal pyrogenic exotoxin B cleaves GSDMA and triggers pyroptosis
    Authors: W Deng, Y Bai, F Deng, Y Pan, S Mei, Z Zheng, R Min, Z Wu, W Li, R Miao, Z Zhang, TS Kupper, J Lieberman, X Liu
    Nature, 2022-02-02;0(0):.  2022-02-02
  7. 2-Chlorodeoxyadenosine (Cladribine) preferentially inhibits the biological activity of microglial cells
    Authors: F Aybar, M Julia Pere, M Silvina Ma, M Eugenia Sa, M Marrodan, J María Pasq, J Correale
    International immunopharmacology, 2022-01-29;105(0):108571.  2022-01-29
  8. LIF, a mitogen for choroidal endothelial cells, protects the choriocapillaris: implications for prevention of geographic atrophy
    Authors: P Li, Q Li, N Biswas, H Xin, T Diemer, L Liu, L Perez Guti, G Paternostr, C Piermarocc, S Domanskyi, RK Wang, N Ferrara
    Embo Molecular Medicine, 2021-11-15;0(0):e14511.  2021-11-15
  9. Mycobacterium tuberculosis inhibits the NLRP3 inflammasome activation via its phosphokinase PknF
    Authors: S Rastogi, S Ellinwood, J Augenstrei, KD Mayer-Barb, V Briken
    PloS Pathogens, 2021-07-29;17(7):e1009712.  2021-07-29
  10. N-3-Hydroxy Dodecanoyl-DL-homoserine Lactone (OH-dDHL) Triggers Apoptosis of Bone Marrow-Derived Macrophages through the ER- and Mitochondria-Mediated Pathways
    Authors: K Woo, DH Kim, MH Oh, HS Park, CH Choi
    International Journal of Molecular Sciences, 2021-07-15;22(14):.  2021-07-15
  11. Selective Anti-Cancer Effects of Plasma-Activated Medium and Its High Efficacy with Cisplatin on Hepatocellular Carcinoma with Cancer Stem Cell Characteristics
    Authors: Y Li, T Tang, HJ Lee, K Song
    International Journal of Molecular Sciences, 2021-04-12;22(8):.  2021-04-12
  12. The Pseudomonas aeruginosa protease LasB directly activates IL-1&beta
    Authors: J Sun, DL LaRock, EA Skowronski, JM Kimmey, J Olson, Z Jiang, AJ O'Donoghue, V Nizet, CN LaRock
    EBioMedicine, 2020-09-23;60(0):102984.  2020-09-23
  13. PD-L1-mediated gasdermin C expression switches apoptosis to pyroptosis in cancer cells and facilitates tumour necrosis
    Authors: J Hou, R Zhao, W Xia, CW Chang, Y You, JM Hsu, L Nie, Y Chen, YC Wang, C Liu, WJ Wang, Y Wu, B Ke, JL Hsu, K Huang, Z Ye, Y Yang, X Xia, Y Li, CW Li, B Shao, JA Tainer, MC Hung
    Nat. Cell Biol., 2020-09-14;0(0):.  2020-09-14
  14. Caspase Activation and Caspase-Mediated Cleavage of APP Is Associated with Amyloid beta-Protein-Induced Synapse Loss in Alzheimer's Disease
    Authors: G Park, HS Nhan, SH Tyan, Y Kawakatsu, C Zhang, M Navarro, EH Koo
    Cell Rep, 2020-06-30;31(13):107839.  2020-06-30
  15. Autophagy controls the induction and developmental decline of NMDAR-LTD through endocytic recycling
    Authors: H Shen, H Zhu, D Panja, Q Gu, Z Li
    Nat Commun, 2020-06-12;11(1):2979.  2020-06-12
  16. Osteogenic impact of pro-apoptotic caspase inhibitors in MC3T3-E1 cells
    Authors: A Kratochvíl, B Veselá, V Ledvina, E Švandová, K Klepárník, K Dadáková, P Beneš, E Matalová
    Sci Rep, 2020-05-04;10(1):7489.  2020-05-04
  17. The mechanism of how CD95/Fas activates the Type I IFN/STAT1 axis, driving cancer stemness in breast cancer
    Authors: AS Qadir, AM Stults, AE Murmann, ME Peter
    Sci Rep, 2020-01-28;10(1):1310.  2020-01-28
  18. DDAH1 regulates apoptosis and angiogenesis in human fetal pulmonary microvascular endothelial cells
    Authors: JK Trittmann, H Almazroue, Y Jin, LD Nelin
    Physiol Rep, 2019-07-01;7(12):e14150.  2019-07-01
  19. Genetic Screen in Chlamydia muridarum Reveals Role for an Interferon-Induced Host Cell Death Program in Antimicrobial Inclusion Rupture
    Authors: AM Giebel, S Hu, K Rajaram, R Finethy, E Toh, JA Brothwell, SG Morrison, RJ Suchland, BD Stein, J Coers, RP Morrison, DE Nelson
    MBio, 2019-04-09;10(2):.  2019-04-09
  20. Cleavage of GSDME by caspase-3 determines lobaplatin-induced pyroptosis in colon cancer cells
    Authors: J Yu, S Li, J Qi, Z Chen, Y Wu, J Guo, K Wang, X Sun, J Zheng
    Cell Death Dis, 2019-02-25;10(3):193.  2019-02-25
  21. PLOD3 suppression exerts an anti-tumor effect on human lung cancer cells by modulating the PKC-delta signaling pathway
    Authors: JH Baek, HS Yun, GT Kwon, J Lee, JY Kim, Y Jo, JM Cho, CW Lee, JY Song, J Ahn, JS Kim, EH Kim, SG Hwang
    Cell Death Dis, 2019-02-15;10(3):156.  2019-02-15
  22. Discovery of the Biginelli hybrids as novel caspase-9 activators in apoptotic machines: Lipophilicity, molecular docking study, influence on angiogenesis gene and miR-21 expression levels
    Authors: N Jankovi?, J Trifunovi?, M Vraneš, A Tot, J Petronijev, N Joksimovi?, T Stanojkovi, M ?or?i? Crn, N Petrovi?, I Boljevi?, IZ Mati?, GA Bogdanovi?, M Mikov, Z Bugar?i?
    Bioorg. Chem., 2019-02-12;86(0):569-582.  2019-02-12
  23. HIV-1 and SIV Infection Are Associated with Early Loss of Lung Interstitial CD4+ T Cells and Dissemination of Pulmonary Tuberculosis
    Authors: B Corleis, AN Bucsan, M Deruaz, VD Vrbanac, AC Lisanti-Pa, SJ Gates, AH Linder, JM Paer, GS Olson, BA Bowman, AE Schiff, BD Medoff, AM Tager, AD Luster, SA Khader, D Kaushal, DS Kwon
    Cell Rep, 2019-02-05;26(6):1409-1418.e5.  2019-02-05
  24. Efficient biofunctionalization of MoS2 nanosheets with peptides as intracellular fluorescent biosensor for sensitive detection of caspase-3 activity
    Authors: X Li, Y Li, Q Qiu, Q Wen, Q Zhang, W Yang, L Yuwen, L Weng, L Wang
    J Colloid Interface Sci, 2019-02-04;543(0):96-105.  2019-02-04
  25. Role of miRNA in the regulation of cannabidiol-mediated apoptosis in neuroblastoma cells
    Authors: E Alharris, NP Singh, PS Nagarkatti, M Nagarkatti
    Oncotarget, 2019-01-01;10(1):45-59.  2019-01-01
  26. Proteolytic cleavage of Beclin 1 exacerbates neurodegeneration
    Authors: G Bieri, KM Lucin, CE O'Brien, H Zhang, SA Villeda, T Wyss-Coray
    Mol Neurodegener, 2018-12-29;13(1):68.  2018-12-29
  27. Pseudomonas aeruginosa ExoS Induces Intrinsic Apoptosis in Target Host Cells in a Manner That is Dependent on its GAP Domain Activity
    Authors: A Kaminski, KH Gupta, JW Goldufsky, HW Lee, V Gupta, SH Shafikhani
    Sci Rep, 2018-09-19;8(1):14047.  2018-09-19
  28. Differentiated Macrophages Acquire a Pro-Inflammatory and Cell Death-Resistant Phenotype Due to Increasing XIAP and P38-mediated inhibition of RipK1
    Authors: D Rijal, A Ariana, A Wight, K Kim, NA Alturki, Z Aamir, E Ametepe, RG Korneluk, C Tiedje, MB Menon, M Gaestel, S McComb, S Sad
    J. Biol. Chem., 2018-06-13;0(0):.  2018-06-13
  29. Balance between senescence and apoptosis is regulated by telomere damage-induced association between p16 and caspase-3
    Authors: S Panneer Se, BM Roth, R Nganga, J Kim, MA Cooley, KL Helke, CD Smith, B Ogretmen
    J. Biol. Chem., 2018-05-10;0(0):.  2018-05-10
  30. Radix Paeoniae Rubra stimulates osteoclast differentiation by activation of the NF-?B and mitogen-activated protein kinase pathways
    Authors: HE Tzeng, CH Tsai, TY Ho, CT Hsieh, SC Chou, YJ Lee, GJ Tsay, PH Huang, YY Wu
    BMC Complement Altern Med, 2018-04-23;18(1):132.  2018-04-23
  31. C33-A cells transfected with E6*I or E6*II the short forms of HPV-16 E6, displayed opposite effects on cisplatin-induced apoptosis
    Authors: CE Vaisman, O Del Moral-, S Moreno-Cam, E Aréchaga-O, R Bonilla-Mo, I Garcia-Agu, L Cedillo-Ba, J Berumen, P Nava, N Villegas-S
    Virus Res., 2018-02-13;247(0):94-101.  2018-02-13
  32. Morin Inhibits Proliferation of SW480 Colorectal Cancer Cells by Inducing Apoptosis Mediated by Reactive Oxygen Species Formation and Uncoupling of Warburg Effect
    Authors: T Sithara, KB Arun, HP Syama, TR Reshmitha, P Nisha
    Front Pharmacol, 2017-09-12;8(0):640.  2017-09-12
  33. Immature human DCs efficiently translocate endocytosed antigens into the cytosol for proteasomal processing
    Authors: RB Baleeiro, P Walden
    Mol. Immunol., 2017-06-20;88(0):148-154.  2017-06-20
  34. Shikonin-induced necroptosis is enhanced by the inhibition of autophagy in non-small cell lung cancer cells
    Authors: HJ Kim, KE Hwang, DS Park, SH Oh, HY Jun, KH Yoon, ET Jeong, HR Kim, YS Kim
    J Transl Med, 2017-05-31;15(1):123.  2017-05-31
  35. Microbiota promotes systemic T-cell survival through suppression of an apoptotic factor
    Authors: R Soto, C Petersen, CL Novis, JL Kubinak, R Bell, WZ Stephens, TE Lane, RS Fujinami, A Bosque, RM O'Connell, JL Round
    Proc. Natl. Acad. Sci. U.S.A., 2017-05-09;0(0):.  2017-05-09
  36. Suberoylanilide hydroxamic acid increases anti-cancer effect of tumor necrosis factor-? through up-regulation of TNF receptor 1 in lung cancer cells.
    Authors: Bo Ra You, Bo Ram Han, Woo Hyun Park
    Oncotarget, 2017-03-14;0(0):1949-2553.  2017-03-14
  37. Hepatitis C Virus Infection of Cultured Human Hepatoma Cells Causes Apoptosis and Pyroptosis in Both Infected and Bystander Cells
    Sci Rep, 2016-12-15;6(0):37433.  2016-12-15
  38. IL-1? is an innate immune sensor of microbial proteolysis
    Authors: CN LaRock, J Todd, DL LaRock, J Olson, AJ O'Donoghue, AA Robertson, MA Cooper, HM Hoffman, V Nizet
    Sci Immunol, 2016-08-19;1(2):.  2016-08-19
  39. Hypoxia potentiates the cytotoxic effect of piperlongumine in pheochromocytoma models
    Oncotarget, 2016-06-28;7(26):40531-40545.  2016-06-28
  40. Macrophage Apoptosis Triggered by IpaD from Shigella flexneri
    Authors: O Arizmendi, WD Picking, WL Picking
    Infect Immun, 2016-05-24;0(0):.  2016-05-24
  41. Stage-specific embryonic antigen-3 (SSEA-3) and beta3GalT5 are cancer specific and significant markers for breast cancer stem cells.
    Authors: Cheung S, Chuang P, Huang H, Hwang-Verslues W, Cho C, Yang W, Shen C, Hsiao M, Hsu T, Chang C, Wong C
    Proc Natl Acad Sci U S A, 2015-12-17;113(4):960-5.  2015-12-17
  42. Caspase-11 Requires the Pannexin-1 Channel and the Purinergic P2X7 Pore to Mediate Pyroptosis and Endotoxic Shock.
    Authors: Yang D, He Y, Munoz-Planillo R, Liu Q, Nunez G
    Immunity, 2015-11-10;43(5):923-32.  2015-11-10
  43. Tumor Necrosis Factor-alpha (TNFalpha)-induced Ceramide Generation via Ceramide Synthases Regulates Loss of Focal Adhesion Kinase (FAK) and Programmed Cell Death.
    Authors: Hernandez-Corbacho M, Canals D, Adada M, Liu M, Senkal C, Yi J, Mao C, Luberto C, Hannun Y, Obeid L
    J Biol Chem, 2015-08-28;290(42):25356-73.  2015-08-28
  44. Source and Purity of Dengue-Viral Preparations Impact Requirement for Enhancing Antibody to Induce Elevated IL-1beta Secretion: A Primary Human Monocyte Model.
    Authors: Callaway J, Smith S, Widman D, McKinnon K, Scholle F, Sempowski G, Dittmer D, Crowe J, de Silva A, Ting J
    PLoS ONE, 2015-08-24;10(8):e0136708.  2015-08-24
  45. Mesenchymal Wnt/beta-Catenin Signaling Controls Epithelial Stem Cell Homeostasis in Teeth by Inhibiting the Antiapoptotic Effect of Fgf10.
    Authors: Yang Z, Balic A, Michon F, Juuri E, Thesleff I
    Stem Cells, 2015-05-01;33(5):1670-81.  2015-05-01
  46. Ethanol extracts of Cinnamomum kanehirai Hayata leaves induce apoptosis in human hepatoma cell through caspase-3 cascade.
    Authors: Liu, Yu-Kuo, Chen, Kuan-Hsi, Leu, Yann-Lii, Way, Tzong-De, Wang, Ling-Wei, Chen, Yu-Jen, Liu, Yu-Ming
    Onco Targets Ther, 2014-12-31;8(0):99-109.  2014-12-31
  47. Dengue viral protease interaction with NF-kappaB inhibitor alpha/beta results in endothelial cell apoptosis and hemorrhage development.
    Authors: Lin J, Lin S, Chen W, Yen Y, Lai C, Tao M, Lin Y, Miaw S, Wu-Hsieh B
    J Immunol, 2014-06-27;193(3):1258-67.  2014-06-27
  48. 5-Fluorouracil-induced apoptosis in colorectal cancer cells is caspase-9-dependent and mediated by activation of protein kinase C-delta
    Authors: Mhaidat N, Bouklihacene M, Thorne R
    Oncol Lett, 2014-06-02;8(2):699-704.  2014-06-02
  49. Anti-apoptotic effect of caspase inhibitors on H(2)O(2)-treated HeLa cells through early suppression of its oxidative stress.
    Authors: Park W
    Oncol Rep, 2014-03-12;31(5):2413-21.  2014-03-12
  50. Suberoylanilide hydroxamic acid-induced HeLa cell death is closely correlated with oxidative stress and thioredoxin 1 levels.
    Authors: You B, Park W
    Int J Oncol, 2014-03-12;44(5):1745-55.  2014-03-12
  51. How liposomal Cisplatin overcomes chemoresistance in ovarian tumour cells.
    Anticancer Res, 2014-01-01;34(1):525-30.  2014-01-01
  52. Purified vitexin compound 1 induces apoptosis through activation of FOXO3a in hepatocellular carcinoma.
    Authors: Wang, Jian-Gan, Zheng, Xing-Xin, Zeng, Guang-Ya, Zhou, Ying-Jun, Yuan, Hong
    Oncol Rep, 2013-11-15;31(1):488-96.  2013-11-15
  53. PX-12 inhibits the growth of A549 lung cancer cells via G2/M phase arrest and ROS-dependent apoptosis.
    Authors: You B, Shin H, Park W
    Int J Oncol, 2013-10-29;44(1):301-8.  2013-10-29
  54. Inhibition of cancer cell proliferation and apoptosis-inducing activity of fungal taxol and its precursor baccatin III purified from endophytic Fusarium solani.
    Authors: Chakravarthi B, Sujay R, Kuriakose G, Karande A, Jayabaskaran C
    Cancer Cell Int, 2013-10-23;13(1):105.  2013-10-23
  55. PX-12-induced HeLa cell death is associated with oxidative stress and GSH depletion.
    Authors: Shin H, You B, Park W
    Oncol Lett, 2013-10-21;6(6):1804-1810.  2013-10-21
  56. Brahma is essential for Drosophila intestinal stem cell proliferation and regulated by Hippo signaling.
    Authors: Jin, Yunyun, Xu, Jinjin, Yin, Meng-Xin, Lu, Yi, Hu, Lianxin, Li, Peixue, Zhang, Peng, Yuan, Zengqian, Ho, Margaret, Ji, Hongbin, Zhao, Yun, Zhang, Lei
    Elife, 2013-10-15;2(0):e00999.  2013-10-15
  57. p62/sequestosome-1 up-regulation promotes ABT-263-induced caspase-8 aggregation/activation on the autophagosome.
    Authors: Huang, Shengbin, Okamoto, Koichi, Yu, Chunrong, Sinicrope, Frank A
    J Biol Chem, 2013-10-11;288(47):33654-66.  2013-10-11
  58. Valproic acid inhibits the growth of HeLa cervical cancer cells via caspase-dependent apoptosis.
    Authors: Han B, You B, Park W
    Oncol Rep, 2013-09-20;30(6):2999-3005.  2013-09-20
  59. HOCl-dependent singlet oxygen and hydroxyl radical generation modulate and induce apoptosis of malignant cells.
    Authors: Bauer G
    Anticancer Res, 2013-09-01;33(9):3589-602.  2013-09-01
  60. Inhibition of nuclear factor-kappa B activation decreases survival of Mycobacterium tuberculosis in human macrophages.
    Authors: Bai X, Feldman N, Chmura K, Ovrutsky A, Su W, Griffin L, Pyeon D, McGibney M, Strand M, Numata M, Murakami S, Gaido L, Honda J, Kinney W, Oberley-Deegan R, Voelker D, Ordway D, Chan E
    PLoS ONE, 2013-04-25;8(4):e61925.  2013-04-25
  61. Anthrax lethal toxin downregulates claudin-5 expression in human endothelial tight junctions.
    Authors: D'Agnillo, Felice, Williams, Matthew, Moayeri, Mahtab, Warfel, Jason M
    PLoS ONE, 2013-04-23;8(4):e62576.  2013-04-23
  62. The novel carboxamide analog ITR-284 induces caspase-dependent apoptotic cell death in human hepatocellular and colorectal cancer cells.
    Authors: Liao Y, Lu C, Lai K, Yang J, Kuo S, Wen Y, Fushiya S, Wu T
    Mol Med Rep, 2013-03-05;7(5):1539-44.  2013-03-05
  63. Zoledronic acid significantly enhances radiationinduced apoptosis against human fibrosarcoma cells by inhibiting radioadaptive signaling.
    Authors: Koto K, Murata H, Kimura S, Sawai Y, Horie N, Matsui T, Ryu K, Ashihara E, Maekawa T, Kubo T, Fushiki S
    Int J Oncol, 2012-12-12;42(2):525-34.  2012-12-12
  64. Axonal degeneration is regulated by the apoptotic machinery or a NAD+-sensitive pathway in insects and mammals.
    Authors: Schoenmann Z, Assa-Kunik E, Tiomny S, Minis A, Haklai-Topper L, Arama E, Yaron A
    J. Neurosci., 2010-05-05;30(18):6375-86.  2010-05-05
  65. Toll-like receptor 9 signaling by CpG-B oligodeoxynucleotides induces an apoptotic pathway in human chronic lymphocytic leukemia B cells.
    Authors: Liang X, Moseman EA, Farrar MA
    Blood, 2010-03-25;115(24):5041-52.  2010-03-25
  66. AMP-activated protein kinase-dependent and -independent mechanisms underlying in vitro antiglioma action of compound C.
    Authors: Vucicevic L, Misirkic M, Janjetovic K, Harhaji-Trajkovic L, Prica M, Stevanovic D, Isenovic E, Sudar E, Sumarac-Dumanovic M, Micic D, Trajkovic V
    Biochem. Pharmacol., 2009-03-14;77(11):1684-93.  2009-03-14
  67. Apoptotic signaling induces hyperpermeability following hemorrhagic shock.
    Authors: Childs EW, Tharakan B, Hunter FA, Tinsley JH, Cao X
    Am. J. Physiol. Heart Circ. Physiol., 2007-02-16;292(6):H3179-89.  2007-02-16
  68. Bakuchiol-induced caspase-3-dependent apoptosis occurs through c-Jun NH2-terminal kinase-mediated mitochondrial translocation of Bax in rat liver myofibroblasts.
    Authors: Park EJ, Zhao YZ, Kim YC, Sohn DH
    Eur. J. Pharmacol., 2007-01-23;559(2):115-23.  2007-01-23
  69. Astrocyte and muscle-derived secreted factors differentially regulate motoneuron survival.
    Authors: Taylor AR, Gifondorwa DJ, Newbern JM, Robinson MB, Strupe JL, Prevette D, Oppenheim RW, Milligan CE
    J. Neurosci., 2007-01-17;27(3):634-44.  2007-01-17
  70. Protective effects of neurotrophic factors on tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-mediated apoptosis of murine adrenal chromaffin cell line tsAM5D.
    Authors: Murata T, Tsuboi M, Hikita K, Kaneda N
    J. Biol. Chem., 2006-06-13;281(32):22503-16.  2006-06-13
  71. Functional proteomics of resveratrol-induced colon cancer cell apoptosis: caspase-6-mediated cleavage of lamin A is a major signaling loop.
    Authors: Lee SC, Chan J, Clement MV, Pervaiz S
    Proteomics, 2006-04-01;6(8):2386-94.  2006-04-01
  72. Acquired resistance to TRAIL-induced apoptosis in human ovarian cancer cells is conferred by increased turnover of mature caspase-3.
    Authors: Lane D, Cote M, Grondin R, Couture MC, Piche A
    Mol. Cancer Ther., 2006-03-01;5(3):509-21.  2006-03-01
  73. Superoxide anions and hydrogen peroxide induce hepatocyte death by different mechanisms: involvement of JNK and ERK MAP kinases.
    Authors: Conde de la Rosa L, Schoemaker MH, Vrenken TE, Buist-Homan M, Havinga R, Jansen PL, Moshage H
    J. Hepatol., 2005-09-12;44(5):918-29.  2005-09-12
  74. Increased sensitivity of early apoptotic cells to complement-mediated lysis.
    Authors: Attali G, Gancz D, Fishelson Z
    Eur. J. Immunol., 2004-11-01;34(11):3236-45.  2004-11-01
  75. Enhancement of stress-induced apoptosis in B-lineage cells by caspase-9 inhibitor.
    Authors: Shah N, Asch RJ, Lysholm AS, Lebien TW
    Blood, 2004-07-08;104(9):2873-8.  2004-07-08
  76. RGDS peptide induces caspase 8 and caspase 9 activation in human endothelial cells.
    Authors: Aguzzi MS, Giampietri C, De Marchis F, Padula F, Gaeta R, Ragone G, Capogrossi MC, Facchiano A
    Blood, 2004-02-24;103(11):4180-7.  2004-02-24
  77. NuMA and nuclear lamins behave differently in Fas-mediated apoptosis.
    Authors: Taimen P, Kallajoki M
    J. Cell. Sci., 2003-02-01;116(0):571-83.  2003-02-01
  78. Apaf-1 is a mediator of E2F-1-induced apoptosis.
    Authors: Furukawa Y, Nishimura N, Furukawa Y, Satoh M, Endo H, Iwase S, Yamada H, Matsuda M, Kano Y, Nakamura M
    J. Biol. Chem., 2002-07-30;277(42):39760-8.  2002-07-30

FAQs

  1. Does R&D Systems offer a negative control for Caspase Inihibitors with benzyloxycarbonyl group (Z-) at the N-terminus and the FMK functional group at the C-terminus?

    • Yes, R&D Systems offers Caspase Inhibitor Control Z-FA-FMK, Catalog # FMKC01, which is an inhibitor of cathepsins B and L but not caspases, and has been used in several systems as a negative control for peptide inhibitors of caspases.

  2. Are R&D Systems Caspase Inhibitors irreversible?

    • Yes, the majority of R&D Systems Caspase Inhibitors have a Fluoromethyl ketone (FMK) functional group on the C-terminus of the peptide, and act as effective irreversible inhibitors with no added cytotoxic effects. Inhibitors synthesized with a benzyloxycarbonyl group (also known as BOC or Z) at the N-terminus and O-methyl side chains exhibit enhanced cellular permeability.

      R&D Systems also offers a General Caspase Inhibitor, Q-VD-OPh, Catalog # OPH001, as well as a FITC-conjugated pan-caspase inhibitor (ApoStat), Catalog # FMK012, which are both cell-permeable, irreversible inhibitors of caspase activity.

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