Candesartan

Catalog #: 4791
4 Citations Datasheet / COA / SDS

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4791/10
4791/50

Candesartan | CAS No. 139481-59-7 | Angiotensin AT1 Receptor Antagonists

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Description: AT1 antagonist

Alternative Names: CV 11974

Chemical Name: 2-Ethoxy-1-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1H-benzimidazole-7-carboxylic acid

Purity: ≥98%

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Product Details

Citations (4)

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Biological Activity

Candesartan is an angiotensin II receptor 1 (AT₁) antagonist (IC₅₀ values are 1.12 and 2.86 nM in bovine adrenal cortex and rabbit aorta, respectively). Exhibits antihypertensive effects in animal models. Also available as a prodrug, candesartan cilexetil (Cat. No. 4792).

Technical Data

M.Wt:

440.45

Formula:

C₂₄H₂₀N₆O₃

Solubility:

Soluble to 100 mM in DMSO and to 10 mM in ethanol with gentle warming

Purity:

≥98%

Storage:

Store at RT

CAS No:

139481-59-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

Pharmacological profile of a highly potent and long-acting angiotensin II receptor antagonist, 2-ethoxy-1-[[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]-1H-benzimidazole-7-carboxylic acid (CV-11974), and its prodrug, (±)-1-(cyclohexyloxycarbonylox
Shibouta et al.
J.Pharmacol.Exp.Ther., 1993;266:114

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Citations for Candesartan

The citations listed below are publications that use Tocris products. Selected citations for Candesartan include:

4 Citations: Showing 1 - 4

Angiotensin type-1 receptor and ACE2 autoantibodies in Parkinson�s disease.
Authors: Rita Et al.
NPJ Parkinsons Dis 2022;8:76
Angiotensin Type-1 Receptor Inhibition Reduces NLRP3 Inflammasome Upregulation Induced by Aging and Neurodegeneration in the Substantia Nigra of Male Rodents and Primary Mesencephalic Cultures.
Authors: Ana Et al.
Antioxidants (Basel) 2022;11
Transcriptomic Analysis of Mouse Brain After Traumatic Brain Injury Reveals That the Angiotensin Receptor Blocker Candesartan Acts Through Novel Pathways.
Authors: Milan Et al.
Front Neurosci 2021;15:636259
Experimental data using candesartan and captopril indicate no double-edged sword effect in COVID-19.
Authors: Gemma Et al.
Clin Sci (Lond) 2021;135:465-481

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