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Calhex 231 hydrochloride

Catalog #: 4387
5 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
4387/10
4387/50
Calhex 231 hydrochloride | CAS No. 2387505-78-2 | Calcium-Sensing Receptor Modulators
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Description: Negative allosteric modulator of calcium-sensing receptor (CaSR)

Chemical Name: 4-Chloro-N-[(1S,2S)-2-[[(1R)-1-(1-naphthalenyl)ethyl]amino]cyclohexyl]-benzamide hydrochloride

Purity: ≥98%

Product Details
Citations (5)
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Biological Activity

Calhex 231 hydrochloride is a negative allosteric modulator of the calcium sensing receptor (CaSR). Blocks increases in [ 3 H]inositol phosphate levels elicited by wild-type hCasR activation (IC 50 = 0.39 μM in transiently transfected HEK293 cells).

Technical Data

M.Wt:
443.41
Formula:
C25H27ClN2O.HCl
Solubility:
Soluble to 50 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
2387505-78-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets

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Citations for Calhex 231 hydrochloride

The citations listed below are publications that use Tocris products. Selected citations for Calhex 231 hydrochloride include:

5 Citations: Showing 1 - 5

  1. Asymmetric dimethylarginine positively modulates calcium-sensing receptor signalling to promote lipid accumulation.
    Authors: Ian P Et al.
    Cell Signal  2023;107:110676
  2. Macrophages in obesity are characterised by increased IL-1β response to calcium-sensing receptor signals.
    Authors: Ulf Et al.
    Int J Obes (Lond)  2022;46:1883-1891
  3. Sensory Axon Growth Requires Spatiotemporal Integration of CaSR and TrkB Signaling.
    Authors: Mathias Et al.
    J Neurosci  2019;39:5842-5860
  4. Calcium-sensing receptor antagonists abrogate airway hyperresponsiveness and inflammation in allergic asthma.
    Authors: Yarova Et al.
    Diabetologia  2015;7:284ra60
  5. Oligopeptides stimulate glucagon-like peptide-1 secretion in mice through proton-coupled uptake and the calcium-sensing receptor.
    Authors: Diakogiannaki Et al.
    Oncotarget  2013;56:2688

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