Bz 423
Chemical Name: 7-Chloro-1,3-dihydro-5-(4-hydroxyphenyl)-1-methyl-3-(2-naphthalenylmethyl)-2H-1,4-benzodiazepin-2-one
Purity: ≥98%
Biological Activity
Bz 423 is an ATP synthase inhibitor (IC50 ~5 μM). Binds the oligomycin sensitivity conferring protein (OSCP) component of mitochondrial F1F0-ATPase in vitro resulting in generation of superoxide and apoptosis. Kills primary B and T cell in mice in vivo. Suppresses autoimmunity and prolongs survival in mouse lupus model.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Identification and validation of the mitochondrial F1F0-ATPase as the molecular target of the immunomodulatory benzodiazepine Bz-423.
Johnson et al.
Chem.Biol., 2005;12:485 -
Bz-423 superoxide signals B cell apoptosis via Mcl-1, Bak, and Bax.
Blatt et al.
Biochem.Pharmacol., 2009;15:966 -
Benzodiazepine-induced superoxide signals B cell apoptosis: mechanistic insight and potential therapeutic utility.
Blatt et al.
J.Clin.Invest., 2002;110:1123
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Citation for Bz 423
The citations listed below are publications that use Tocris products. Selected citations for Bz 423 include:
1 Citation: Showing 1 - 1
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Impaired flickering of the permeability transition pore causes SPG7 spastic paraplegia.
Authors: Giorgia Et al.
EBioMedicine 2020;61:103050
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