BTS
Chemical Name: 4-Methyl-N-(phenylmethyl)benzenesulfonamide
Purity: ≥99%
Biological Activity
BTS is a selective inhibitor of the ATPase activity of skeletal muscle myosin II subfragment 1 (S1) (IC50 ~ 5 mM). Reversibly blocks gliding motility and suppresses force and twitch production in fast skeletal muscle.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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A small-molecule inhibitor of skeletal muscle myosin II.
Cheung et al.
Nat.Cell.Biol., 2001;4:83 -
Skeletal muscle myosin cross-bridge cycling is necessary for myofibrillogenesis.
Ramachandran et al.
Cell Motil.Cytoskeleton, 2003;55:61 -
Mechanism of inhibition of skeletal muscle actomyosin by N-benzyl-p-toluenesulfonamide.
Shaw et al.
Biochemistry, 2003;42:6128
Product Datasheets
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Citations for BTS
The citations listed below are publications that use Tocris products. Selected citations for BTS include:
5 Citations: Showing 1 - 5
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Early redox activities modulate Xenopus tail regeneration.
Authors: Ferreira Et al.
Nat Commun 2018;9:4296
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Direct optical activation of skeletal muscle fibres efficiently controls muscle contraction and attenuates denervation atrophy.
Authors: Magown Et al.
Nat Commun 2015;6:8506
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Ca(2+) permeation and/or binding to CaV1.1 fine-tunes skeletal muscle Ca(2+) signaling to sustain muscle function.
Authors: Lee Et al.
FASEB J 2015;5:4
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Firefly luciferase in chemical biology: a compendium of inhibitors, mechanistic evaluation of chemotypes, and suggested use as a reporter.
Authors: Thorne Et al.
Chem Biol 2012;19:1060
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The I4895T mutation in the type 1 ryanodine receptor induces fiber-type specific alterations in skeletal muscle that mimic premature aging.
Authors: Boncompagni Et al.
Aging Cell 2010;9:958
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