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BSJ-03-204

Catalog #: 6938
1 Citation Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
6938/5
BSJ-03-204 | CAS No. 2349356-09-6 | Active Degraders
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Description: Selective Cdk4/6 Degrader (PROTAC®)

Chemical Name: N-[4-[4-[6-[(6-Acetyl-8-cyclopentyl-7,8-dihydro-5-methyl-7-oxopyrido[2,3-d]pyrimidin-2-yl)amino]-3-pyridinyl]-1-piperazinyl]butyl]-2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]acetamide

Purity: ≥98%

Product Details
Citations (1)
Reviews
Biological Activity Technical Data Additional Information Background Product Datasheets Calculators

Biological Activity

BSJ-03-204 is a selective Cdk4/6 Degrader (PROTAC®). Displays cereblon-dependent degradation with no effect on IKZF1/3 in Molt4 cells. Induces degradation of Cdk4/6 and G1 cell cycle arrest, and inhibits cell proliferation in a mantle cell lymphoma (MCL) cell line.

PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.

Technical Data

M.Wt:
832.92
Formula:
C43H48N10O8
Solubility:
Soluble to 20 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
2349356-09-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold under license from Dana-Farber Cancer Institute

Background References

  1. Development of dual and selective degraders of cyclin-dependent kinases 4 and 6.
    Jiang et al.
    Angew.Chem.Int.Ed.Engl., 2019;58:6321

Product Datasheets

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Citation for BSJ-03-204

The citations listed below are publications that use Tocris products. Selected citations for BSJ-03-204 include:

1 Citation: Showing 1 - 1

  1. A Tale of Two Tails: Efficient Profiling of Protein Degraders by Specific Functional and Target Engagement Readouts.
    Authors: Daniele Et al.
    SLAS Discov  2021;26:534-546

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