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Brequinar sodium

Catalog #: 6196
3 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
6196/50
6196/10
Brequinar sodium | CAS No. 96201-88-6 | DHODH Inhibitors
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Description: Potent and selective DHODH inhibitor
Alternative Names: BRQ,DuP 785,NSC 368390

Chemical Name: 6-Fluoro-2-(2'-fluoro[1,1'-biphenyl]-4-yl)-3-methyl-4-quinolinecarboxylic acid sodium

Purity: ≥99%

Product Details
Citations (3)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

Brequinar sodium is a potent and selective dihydroorotate dehydrogenase (DHODH) inhibitor (IC50 = ~20 nM). Causes depletion of pyrimidine nucleotides. Exhibits minimal inhibition against a panel of >400 kinases. Triggers differentiation of AML cell lines (ED50 = ~ 1 μM. Note uridine concentration effects ED50 value). Causes differentiation and depletion of leukemia-initiating cells in vivo. Antimetabolite.

Technical Data

M.Wt:
397.35
Formula:
C23H14F2NO2Na
Solubility:
Soluble to 100 mM in water and to 100 mM in DMSO
Purity:
≥99%
Storage:
Store at +4°C
CAS No:
96201-88-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for Brequinar sodium

The citations listed below are publications that use Tocris products. Selected citations for Brequinar sodium include:

3 Citations: Showing 1 - 3

  1. Proof-of-principle studies on a strategy to enhance nucleotide imbalance specifically in cancer cells.
    Authors: Juan Et al.
    Cell Death Discov  2022;8:464
  2. DHODH inhibition modulates glucose metabolism and circulating GDF15, and improves metabolic balance.
    Authors: Sonia Et al.
    iScience  2021;24:102494
  3. Inhibition of the de novo pyrimidine biosynthesis pathway limits ribosomal RNA transcription causing nucleolar stress in glioblastoma cells.
    Authors: Jessica A Et al.
    PLoS Genet  2020;16:e1009117

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