BIO 5192

Biological Activity

BIO 5192 is a highly selective and potent inhibitor of integrin α₄β₁ (Very Late Antigen-4; VLA-4) (K_d < 10 pM). Selectively binds α₄β₁ over a range of other integrins (IC₅₀ values are 1.8, 138, 1053, > 500 and > 10,000 nM for α₄β₁, α₉β₁, α₂β₁, α₄β₇ and α_IIbβ₃, respectively). Induces a 30-fold increase in mobilization of murine hematopoietic stem and progenitor cells; displays a 3-fold additive effect with AMD 3100 (Cat. No. 3299). Decreases oxidative damage and improves neurological function following spinal cord injury in rats.

Technical Data

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

1. A chemical approach to stem-cell biology and regenerative medicine.
   Xu et al.
   Nature, 2008;453:338
2. BIO5192, a small molecule inhibitor of VLA-4, mobilizes hematopoietic stem and progenitor cells.
   Ramirez et al.
   Blood., 2009;1340:1340
3. An integrin inhibiting molecule decreases oxidative damage and improves neurological function after spinal cord injury.
   Bao et al.
   Exp.Neurol, 2008;214:160
4. An assessment of the mechanistic differences between two integrin α4β1 inhibitors, the monoclonal antibody TA-2 and the small molecule BIO5192, in rat experimental aut
   Leone et al.
   J.Pharmacol.Exp.Ther., 2003;305:1150

Product Datasheets