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Belinostat

Catalog #: 7981 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
7981/10
7981/50
Belinostat | CAS No. 866323-14-0 | Histone Deacetylase Inhibitors
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Description: Potent pan-HDAC inhibitor

Chemical Name: (2E)-N-Hydroxy-3-[3-[(phenylamino)sulfonyl]phenyl]-2-propenamide

Purity: ≥98%

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Biological Activity

Belinostat is a potent pan-HDAC inhibitor (IC50 = 28 nM). Dose-dependently reduces tumor volume in a rat model of glioblastoma and induces 70% and 28% apoptosis in LN-229 and LN-18 glioma cell lines (IC50 values are 210 nM and 300 nM respectively). In H358 cells, Belinostat dose-dependently reduces cell viability and upregulates amino acids and metabolites of the TCA and urea cycle. Also potently inhibits C4 release from stem cell-derived astrocytes and shows antidepressant activity. Belinostat is brain penetrant.

Technical Data

M.Wt:
318.35
Formula:
C15H14N2O4S
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
866323-14-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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