BAM 22P

Name: BAM 22P
Brand: Tocris Bioscience
SKU: 1650

Catalog #: 1650
1 Citation Datasheet / COA / SDS

Discontinued Product

1650 has been discontinued.

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Description: MRGPRX1 agonist; also opioid receptor agonist

Alternative Names: Bovine adrenal medullary peptide-22P,BAM 22 (1-22)

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Product Details

Citations (1)

Reviews

Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

Potent endogenous agonist peptide for Mas-related G proteins-coupled receptor X1 (MRGPRX1); isolated from bovine adrenal medulla (EC₅₀ values are 16 - 800 nM) Also potent opioid agonist (IC₅₀ = 1.3 nM in guinea pig ileum preparation). Produces opioid- and non-opioid receptor mediated antinociceptive effects in vivo.

Technical Data

M.Wt:

2839.24

Formula:

C₁₃₀H₁₈₄N₃₈O₃₁S₂

Sequence:

YGGFMRRVGRPEWWMDYQKRYG

Solubility:

Soluble to 1 mg/ml in water

Storage:

Desiccate at -20°C

CAS No:

76622-26-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

Dual effects of intrathecal BAM22 on nociceptive responses in acute and persistent pain - potential function of a novel receptor.
Hong et al.
Br.J.Pharmacol., 2004;141:423
Proenkephalin A gene products activate a new family of sensory neuron-specific GPCRs.
Lembo et al.
Nat.Neurosci., 2002;5:201
A new family of endogenous "big" met-enkephalins from bovine adrenal medulla: purification and structure of docosa- (BAM-22P) and eicosapeptide (BAM-20P) with very potent opiate activity.
Mizuno et al.
Biochem.Biophys.Res.Commun., 1980;97:1283
Two faces for an opioid peptide - and more receptors for pain research.
Simonin and Kieffer
Nat.Neurosci., 2002;5:185
Pharmacology and signaling of MAS-related G protein-coupled receptors.
Solinski et al.
Pharmacol.Rev., 2014;66:570

Product Datasheets

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Citation for BAM 22P

The citations listed below are publications that use Tocris products. Selected citations for BAM 22P include:

1 Citation: Showing 1 - 1

Opioid receptor function is regulated by post-endocytic peptide processing.
Authors: Gupta Et al.
J Biol Chem 2014;289:19613

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