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B I09

Catalog #: 6009
1 Citation Datasheet / COA / SDS
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6009/50
6009/10
B I09 | CAS No. 1607803-67-7 | IRE1 Inhibitors
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Description: IRE1 endonuclease inhibitor; cell permeable

Chemical Name: 7-(1,3-Dioxan-2-yl)-1,2,3,4-tetrahydro-8-hydroxy-5H-[1]benzopyrano[3,4-c]pyridin-5-one

Purity: ≥98%

Product Details
Citations (1)
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Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

B I09 is an IRE-1 RNase inhibitor (IC50 = 1.23 μM). Inhibits IRE-1/XBP1 pathway. Cell permeable. Inhibits growth of human chronic lymphocytic leukemia (CLL) cells in vitro and promotes CLL regression in a mouse model.

Technical Data

M.Wt:
303.31
Formula:
C16H17NO5
Solubility:
Soluble to 50 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
1607803-67-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Inhibition of ER stress-associated IRE-1/XBP-1 pathway reduces leukemic cell survival.
    Tang et al.
    J.Clin.Invest., 2014;124:2585

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Citation for B I09

The citations listed below are publications that use Tocris products. Selected citations for B I09 include:

1 Citation: Showing 1 - 1

  1. Targeting the IRE1α/XBP1 Endoplasmic Reticulum Stress Response Pathway in ARID1A-Mutant Ovarian Cancers.
    Authors: Andrew V Et al.
    Cancer Res  2021;81:5325-5335

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