AR 420626
Chemical Name: N-(2,5-Dichlorophenyl)-4-(furan-2-yl)-2-methyl-5-oxo-1,4,5,6,7,8-hexahydroquinoline-3-carboxamide
Purity: ≥98%
Biological Activity
AR 420626 is a FFA3 agonist (pEC50 = 5.74). Inhibits nicotine and serotonin induced changes in motility of isolated muscle strips from rat colon. Also suppresses serotonin-induced fecal output in rats.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Complex pharmacology of novel allosteric free fatty acid 3 receptor ligands.
Hudson et al.
Mol Pharmacol., 2014;86:200 -
Free fatty acid receptor 3 activation suppresses neurogenic motility in rat proximal colon.
Kaji et al.
Neurogastroenterol.Motil., 2017;30
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