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AMG 18 hydrochloride

Catalog #: 6166
2 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
6166/5
AMG 18 hydrochloride | CAS No. 2250019-92-0 | IRE1 Inhibitors
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Description: Potent and selective IRE1α inhibitor

Chemical Name: 2-Chloro-N-[6-methyl-5-[[3-[2-[(3S)-3-piperidinylamino]-4-pyrimidinyl]-2-pyridinyl]oxy]-1-naphthalenyl]benzenesulfonamide hydrochloride

Purity: ≥98%

Product Details
Citations (2)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

AMG 18 hydrochloride is a potent and selective IRE1α inhibitor (IC50 values are 13 and 99 nM for recombinant and cellular IRE1α, respectively). Exhibits selectivity for IRE1α in a panel of over 100 other kinases.

Technical Data

M.Wt:
637.58
Formula:
C31H29ClN6O3S.HCl
Solubility:
Soluble to 100 mM in water and to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
2250019-92-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets

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Citations for AMG 18 hydrochloride

The citations listed below are publications that use Tocris products. Selected citations for AMG 18 hydrochloride include:

2 Citations: Showing 1 - 2

  1. Targeting IRE1 endoribonuclease activity alleviates cardiovascular lesions in a murine model of Kawasaki disease vasculitis.
    Authors: Michael C Et al.
    JCI Insight  2022;7
  2. The E3 ligase Hrd1 stabilizes Tregs by antagonizing inflammatory cytokine-induced ER stress response.
    Authors: Xu Et al.
    JCI Insight  2019;4

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