Home / Melanocortin Receptor Agonists / α-MSH

α-MSH

Catalog #: 2584
2 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
2584/1
α-MSH
1 Image
Description: Endogenous melanocortin receptor agonist
Alternative Names: α-Melanotropin,α-Melanocyte-stimulating hormone

Purity: ≥95%

Product Details
Citations (2)
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Biological Activity

α-MSH is an endogenous melanocortin receptor agonist (Ki values are 0.12, 31, 660 and 5700 nM for MC1, MC3, MC4 and MC5 receptors respectively). Anti-inflammatory peptide; antagonizes proinflammatory mediators, including TNF-α, IL-6 and NO and induces anti-inflammatory cytokine IL-10. Inhibits food intake and induces penile erections following i.c.v. administration.

Technical Data

M.Wt:
1664.9
Formula:
C77H109N21O19S
Sequence:
SYSMEHFRWGKPV

(Modifications: Ser-1 = N-terminal Ac, Val-13 = C-terminal amide)

Solubility:
Soluble to 0.60 mg/ml in water
Purity:
≥95%
Storage:
Store at -20°C
CAS No:
581-05-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for α-MSH

The citations listed below are publications that use Tocris products. Selected citations for α-MSH include:

2 Citations: Showing 1 - 2

  1. Re-evaluation of Adrenocorticotropic Hormone and Melanocyte Stimulating Hormone Activation of GPR139 in Vitro.
    Authors: Nepomuceno Et al.
    Front Pharmacol  2018;9:157
  2. The orphan G protein-coupled receptor GPR139 is activated by the peptides: Adrenocorticotropic hormone (ACTH), α-, and β-melanocyte stimulating hormone (α-MSH, and β-MSH), and the conserved core motif HFRW.
    Authors: Nøhr Et al.
    Neurochem Int  2017;102:105

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