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Allopregnanolone

Catalog #: 3653
5 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
3653/10
Allopregnanolone | CAS No. 516-54-1 | GABA-A Receptor Modulators
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Description: Positive allosteric modulator of GABAA receptors
Alternative Names: 3a,5a-THPROG

Chemical Name: (3α,5α)-3-Hydroxy-pregnan-20-one

Product Details
Citations (5)
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Biological Activity Technical Data Additional Information Background Product Datasheets Calculators

Biological Activity

Allopregnanolone is a GABAA receptor positive allosteric modulator. Neuroactive steroid.

Technical Data

M.Wt:
318.49
Formula:
C21H34O2
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Storage:
Store at RT
CAS No:
516-54-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Other Product-Specific Information:

Background References

  1. Neurosteroids act on recombinant human GABAA receptors.
    Puia et al.
    Neuron, 1990;4:759
  2. Neurosteroids: endogenous regulators of the GABAA receptor.
    Belelli and Lambert
    Nat.Rev.Neurosci., 2005;6:565
  3. Characterization of brain neurons that express enzymes mediating neurosteroid biosynthesis.
    Agis-Balboa et al.
    Proc.Natl.Acad.Sci.USA, 2006;103:14602

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Citations for Allopregnanolone

The citations listed below are publications that use Tocris products. Selected citations for Allopregnanolone include:

5 Citations: Showing 1 - 5

  1. Placental endocrine function shapes cerebellar development and social behavior.
    Authors: Michael Et al.
    Nat Neurosci  2021;24:1392-1401
  2. Pubertal adversity alters chromatin dynamics and stress circuitry in the pregnant brain.
    Authors: Scott M Et al.
    Neuropsychopharmacology  2020;45:1263-1271
  3. Pubertal adversity alters chromatin dynamics and stress circuitry in the pregnant brain.
    Authors: Scott M Et al.
    Neuropsychopharmacology  2020;45:1263
  4. Altered gamma oscillations during pregnancy through loss of δ subunit-containing GABA(A) receptors on parvalbumin interneurons.
    Authors: Ferando and Mody
    Front Neural Circuits  2013;7:144
  5. Inhibition of recombinant L-type voltage-gated calcium channels by positive allosteric modulators of GABAA receptors.
    Authors: Earl
    J Pharmacol Exp Ther  2011;337:301

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