Home / Free Fatty Acid Receptor Antagonists / AH 7614

AH 7614

Catalog #: 5256
2 Citations Datasheet / COA / SDS
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5256/10
5256/50
AH 7614 | CAS No. 6326-06-3 | Free Fatty Acid Receptor Antagonists
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Description: Selective FFA4 (GPR120) antagonist

Chemical Name: 4-Methyl-N-9H-xanthen-9-yl-benzenesulfonamide

Purity: ≥98%

Product Details
Citations (2)
Supplemental Products
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Biological Activity Technical Data Additional Information Background Product Datasheets Calculators

Biological Activity

AH 7614 is a selective free fatty acid receptor 4 (FFA4/GPR120) antagonist (pIC50 values are 7.1 and <4.6 for human FFA4 and FFA1 receptors respectively). Inhibits linoleic acid and GSK 137647A-induced intracellular calcium accumulation in U2OS osteosarcoma cells expressing the FFA4 receptor.

Technical Data

M.Wt:
351.42
Formula:
C20H17NO3S
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
6326-06-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold for research purposes under agreement from GlaxoSmithKline

Background References

  1. Identification of diarylsulfonamides as agonists of the free fatty acid receptor 4 (FFA4/GPR120).
    Sparks et al.
    Bioorg.Med.Chem.Lett., 2014;24:3100
  2. Secreted Phospholipase PLA2G2D Contributes to Metabolic Health by Mobilizing ?3 Polyunsaturated Fatty Acids in WAT
    H Sato, Y Taketomi, Y Miki, R Murase, K Yamamoto, M Murakami
    Cell Rep, 2020;31(5):107579.

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Citations for AH 7614

The citations listed below are publications that use Tocris products. Selected citations for AH 7614 include:

2 Citations: Showing 1 - 2

  1. Docosahexaenoic Acid Inhibits Inflammation-Induced Osteoclast Formation and Bone Resorption in vivo Through GPR120 by Inhibiting TNF-α Production in Macrophages and Directly Inhibiting Osteoclast Formation.
    Authors: Kishikawa Et al.
    Front Endocrinol (Lausanne)  2019;10:157
  2. Extracorporeal shockwave against inflammation mediated by GPR120 receptor in cyclophosphamide-induced rat cystitis model.
    Authors: Chen Et al.
    Mol Med  2018;24:60

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