A 971432

Catalog #: 5766
1 Citation Datasheet / COA / SDS

Catalog #	Availability	Size / Price	Qty
5766/10
5766/50

A 971432 | CAS No. 1240308-45-5 | Sphingosine-1-phosphate Receptor Agonists

1 Image

Description: Potent and selective S1P5 agonist

Chemical Name: 1-[[4-[(3,4-Dichlorophenyl)methoxy]phenyl]methyl]-3-azetidinecarboxylic acid

Purity: ≥99%

View All Products for Sphingosine-1-phosphate Receptor Agonists

Product Details

Citations (1)

Supplemental Products

Reviews

Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

A 971432 is a potent and selective S1P₅ agonist (EC₅₀ values are 4.1 and 5.7 nM in cAMP and GTPγS assays, respectively). Exhibits 60-fold selectivity over S1P₁, and >1,600-fold selectivity over S1P_2-4, and a panel of 129 kinases and 79 receptors. Improves blood-brain barrier integrity in vitro and reverses age-related cognitive decline in vivo. Orally available.

Technical Data

M.Wt:

366.24

Formula:

C₁₈H₁₇Cl₂NO₃

Solubility:

Soluble to 100 mM in 1eq. NaOH and to 100 mM in 1eq. HCl

Purity:

≥99%

Storage:

Store at RT

CAS No:

1240308-45-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

Discovery of A-971432, an orally bioavailable selective sphingosine-1-phosphate receptor 5 (S1P₅) agonist for the potential treatment of neurodegenerative disorders.
Hobson et al.
J.Med.Chem., 2015;58:9154

Product Datasheets

COA view current batch

SDS

Reconstitution Calculator

Molarity Calculator

Reconstitution Calculator

Molarity Calculator

Mass

Concentration

Volume

M. Wt* g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Citation for A 971432

The citations listed below are publications that use Tocris products. Selected citations for A 971432 include:

1 Citation: Showing 1 - 1

Sphingosine 1-phosphate (S1P) reduces hepatocyte growth factor-induced migration of hepatocellular carcinoma cells via S1P receptor 2.
Authors: Matsushima-Nishiwaki Et al.
PLoS One 2018;13:e0209050

FAQs

No product specific FAQs exist for this product, however you may

View all Small Molecule FAQs

Reviews for A 971432

There are currently no reviews for this product. Be the first to review A 971432 and earn rewards!

Have you used A 971432?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.