6877002
Chemical Name: 3-[(2,5-Dimethylphenyl)amino]-1-phenyl-2-propen-1-one
Purity: ≥99%
Biological Activity
6877002 is a CD40-TRAF6 interaction inhibitor. Suppresses CD40-induced IL-1β and IL-6 expression in macrophages in vitro. Improves insulin sensitivity, reduces adipose tissue inflammation, and ameliorates hepatosteatosis in diet-induced obese mice.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Blocking CD40-TRAF6 signaling is a therapeutic target in obesity-associated Ins resistance.
Chatzigeorgiou et al.
Proc.Natl.Acad.Sci.U.S.A., 2014;111:2686
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