5-Carboxamidotryptamine maleate

Biological Activity

Technical Data

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

1. High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death.
   Fox JT, Sakamuru S, Huang R
   Proc. Natl. Acad. Sci. U.S.A., 2012;109(14):5423-8.
2. A Miniaturized Screen of a Schistosoma mansoni Serotonergic G Protein-Coupled Receptor Identifies Novel Classes of Parasite-Selective Inhibitors
   
   PLoS Pathog, 2016;12(5):e1005651.
3. Targeted inhibition of serotonin type 7 (5-HT7) receptor function modulates immune responses and reduces the severity of intestinal inflammation.
   Kim, Janice J, Bridle, Byram W, Ghia, Jean-Eri, Wang, Huaqing, Syed, Shahzad, Manocha, Marcus M, Rengasamy, Palanive, Shajib, Mohammad, Wan, Yonghong, Hedlund, Peter B, Khan, Waliul I
   J Immunol, 2013;190(9):4795-804.
4. [³H]-5-carboxamidotryptamine labels 5HT_1D binding sites in bovine substantia nigra.
   Nowak et al.
   Br.J.Pharmacol., 1993;109:1206
5. Antagonist activity of meta-chlorophenylpiperazine and partial agonist activity of 8-OH-DPAT at the 5-HT₇ receptor.
   Wood et al.
   Eur.J.Pharmacol., 2000;396:1
6. 5-Hydroxytryptamine receptors.
   Zifa and Fillion
   Pharmacol.Rev., 1992;44:401
7. An investigation of the 5-HT_1D receptor binding affinity of 5-hydroxytryptamine, 5-carboxyamidotryptamine and sumatr. in the central nervous system of seven species.
   Beer et al.
   Eur.J.Pharmacol., 1992;213:193

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