4-DAMP
Chemical Name: 1,1-Dimethyl-4-diphenylacetoxypiperidinium iodide
Purity: ≥99%
Biological Activity
4-DAMP is an antagonist at the M3 cholinergic receptor. [3H]-4-DAMP selectively labels M1 and M3 receptors.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death.
Fox JT, Sakamuru S, Huang R
Proc. Natl. Acad. Sci. U.S.A., 2012;109(14):5423-8. -
A further search for selective antagonists at M2- muscarinic receptors.
Barlow and Shepherd
Br.J.Pharmacol., 1986;89:837 -
Direct labelling of rat M3-muscarinic receptors by [3H]4-DAMP.
Michel et al.
Eur.J.Pharmacol., 1989;166:459
Product Datasheets
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Citations for 4-DAMP
The citations listed below are publications that use Tocris products. Selected citations for 4-DAMP include:
16 Citations: Showing 1 - 10
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SOX2 regulates acinar cell development in the salivary gland.
Authors: Emmerson Et al.
Elife 2017;6
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Regulation of nerve-evoked contractions of rabbit vas deferens by acetylcholine.
Authors: Wallace Et al.
Microvasc Res 2015;3
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Diadenosine tetraphosphate contributes to CB-induced tear secretion.
Authors: Fonseca Et al.
Purinergic Signal 2015;11:87
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M2 Muscarinic acetylcholine receptor modulates rat airway smooth muscle cell proliferation.
Authors: Placeres-Uray Et al.
World Allergy Organ J 2014;6:22
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Parasympathetic innervation regulates tubulogenesis in the developing salivary gland.
Authors: Nedvetsky Et al.
Dev Cell 2014;30:449
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M2muscarinic receptors inhibit cell proliferation and migration in urothelial bladder cancer cells.
Authors: Pacini Et al.
Cancer Biol Ther 2014;15:1489
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An acetylcholinesterase inhibitor, eserine, induces long-term depression at CA3-CA1 synapses in the hippocampus of adult rats.
Authors: Mans Et al.
J Neurophysiol 2014;112:2388
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A drug repositioning approach identifies tricyclic antidepressants as inhibitors of small cell lung cancer and other neuroendocrine tumors.
Authors: Jahchan Et al.
Cancer Discov 2013;3:1364
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Muscarinic type 3 receptor induces cytoprotective signaling in salivary gland cells through epidermal growth factor receptor transactivation.
Authors: Kajiya Et al.
J Neurosci 2012;82:115
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Mechanism of all-trans-retinal toxicity with implications for stargardt disease and age-related macular degeneration.
Authors: Chen Et al.
J Biol Chem 2012;287:5059
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Signaling pathways used by EGF to stimulate conjunctival goblet cell secretion.
Authors: Hodges Et al.
Exp Eye Res 2012;103:99
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Differential roles of M2 and M3 muscarinic receptor subtypes in modulation of bladder afferent activity in rats.
Authors: Matsumoto Et al.
Urology 2010;75:862
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M3 muscarinic receptors mediate positive inotropic responses in mouse atria: a study with muscarinic receptor knockout mice.
Authors: Kitazawa Et al.
Mol Pharmacol 2009;330:487
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Cholinergic innervation of the guinea-pig isolated vas deferens.
Authors: Solanki Et al.
Naunyn Schmiedebergs Arch Pharmacol 2007;376:265
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Coregulation of natively expressed pertussis toxin-sensitive muscarinic receptors with G-protein-activated potassium channels.
Authors: Clancy Et al.
Physiol Rep 2007;27:6388
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In vivo antimuscarinic actions of the third generation antihistaminergic agent, deslorat.
Authors: Howell Et al.
BMC Pharmacol 2005;5:13
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