2',3'-cGAMP sodium salt
Chemical Name: 2',3'-Cyclic guanosine monophosphate-adenosine monophosphate sodium salt
Purity: ≥98%
Biological Activity
2',3'-cGAMP sodium salt is a endogenous high affinity STING agonist (Kd values are 3.79 and 120 nM for human and rat STING, respectively). Induces repolarization of M2 macrophages in vitro.This product is sold in units of 359μg, equivalent to 0.5μmol.
Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Additional Information
- This product is sold in units of 359μg, equivalent to 0.5μmol.
Background References
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Rat and human STINGs profile similarly towards anticancer/antiviral compounds.
Zhang et al.
Sci. Rep., 2015;5:18035 -
Cyclic GMP-AMP containing mixed phosphodiester linkages is an endogenous high-affinity ligand for STING.
Zhang et al.
Mol.Cell., 2013;51:226 -
DMXAA causes tumor site-specific vascular disruption in murine non-small cell lung cancer, and like the endogenous non-canonical cyclic dinucleotide STING agonist, 2'3'-cGAMP, induces M2 macrophage repolarization.
Downey et al.
PLoS One, 2014;9:e99988
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