2'-MeCCPA
Chemical Name: 2-Chloro-N-cyclopentyl-2'-methyladenosine
Purity: ≥98%
Biological Activity
2'-MeCCPA is a potent and highly selective agonist at A1 adenosine receptors (Ki values are 3.3, 9580, 37600 and 1150 nM for human recombinant A1, A2A, A2B and A3 receptors respectively). Acts as a full agonist; inhibits forskolin-stimulated adenylyl cyclase activity in rat cortical membranes with an IC50 value of 13.1 nM.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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2'-C-Methyl analogues of selective adenosine receptor agonists: synthesis and binding studies.
Franchetti et al.
J.Med.Chem., 1998;41:1708 -
Synthesis, biological evaluation, and molecular modeling of ribose-modified adenosine analogues as adenosine receptor agonists.
Cappellacci et al.
J.Med.Chem., 2005;48:1550
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Citations for 2'-MeCCPA
The citations listed below are publications that use Tocris products. Selected citations for 2'-MeCCPA include:
2 Citations: Showing 1 - 2
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Adenosine binds predominantly to adenosine receptor A1 subtype in astrocytes and mediates an immunosuppressive effect.
Authors: Liu Et al.
Brain Res 2018;1700:47
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Adenosine mediated desensitization of cAMP signaling enhances T-cell responses.
Authors: Yang Et al.
Eur J Immunol 2010;40:449
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