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2-Hydroxysaclofen

Catalog #: 0245
2 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
0245/10
0245/50
2-Hydroxysaclofen | CAS No. 117354-64-0 | GABA-B Receptor Antagonists
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Description: Selective GABAB antagonist; more potent than Saclofen (Cat. No. 0246)

Chemical Name: (RS)-3-Amino-2-(4-chlorophenyl)-2-hydroxypropyl-sulfonic acid

Product Details
Citations (2)
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Biological Activity

2-Hydroxysaclofen is a selective antagonist at GABAB receptors.

Technical Data

M.Wt:
265.71
Formula:
C9H12ClNO4S
Solubility:
Soluble to 5 mM in water and to 100 mM in 1eq. NaOH
Storage:
Store at RT
CAS No:
117354-64-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death.
    Fox JT, Sakamuru S, Huang R
    Proc. Natl. Acad. Sci. U.S.A., 2012;109(14):5423-8.
  2. Baclofen antagonism by 2-hydroxysaclofen in the cat spinal cord.
    Curtis et al.
    Neurosci.Lett., 1988;92:97
  3. 2-Hydroxysaclofen: an improved antagonist at central and peripheral GABAB receptors.
    Kerr et al.
    Neurosci.Lett., 1988;92:92

Product Datasheets

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Citations for 2-Hydroxysaclofen

The citations listed below are publications that use Tocris products. Selected citations for 2-Hydroxysaclofen include:

2 Citations: Showing 1 - 2

  1. Peripheral GABAB agonists stimulate gastric acid secretion in mice.
    Authors: Piqueras and Martínez
    Br J Pharmacol  2004;142:1038
  2. Physiological contribution of the astrocytic environment of neurons to intersynaptic crosstalk.
    Authors: Piet Et al.
    Nature  2004;101:2151

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