2-Furoyl-LIGRLO-amide

Catalog #: 3015
3 Citations Datasheet / COA / SDS

Catalog #	Availability	Size / Price	Qty
3015/1

1 Image

Description: Potent and selective PAR2 agonist

Purity: ≥95%

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Product Details

Citations (3)

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Biological Activity

2-Furoyl-LIGRLO-amide is a potent and selective PAR₂ receptor agonist (pD₂ = 7.0). Causes a dose-dependent relaxation of murine femoral arteries.

Technical Data

M.Wt:

777.96

Formula:

C₃₆H₆₃N₁₁O₈

Sequence:

LIGRLX

(Modifications: Leu-1 = 2-Furoyl-Leu, X = Orn & C-terminal amide)

Solubility:

Soluble to 1 mg/ml in water

Purity:

≥95%

Storage:

Store at -20°C

CAS No:

729589-58-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

2-Furoyl-LIGRLO-amide: a potent and selective proteinase-activated receptor 2 agonist.
McGuire et al.
J.Pharmacol.Exp.Ther., 2004;309:1124
A protease activated receptor-2 (PAR-2) activating peptide, tc-LIGRLO-NH₂, induces protease release from mast cells: role in TNF degradation.
Alshurafa et al.
BMC Pharmacol., 2004;4:12
Proteinase-activated receptors 1 and 2 in rat olfactory system: layer-specific regulation of multiple signaling pathways in the main olfactory bulb and induction of neurite retraction in olfactory sensory neurons.
Olianas et al.
Neuroscience, 2007;146:1289

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Citations for 2-Furoyl-LIGRLO-amide

The citations listed below are publications that use Tocris products. Selected citations for 2-Furoyl-LIGRLO-amide include:

3 Citations: Showing 1 - 3

Protease-activated receptor 2 protects against VEGF inhibitor-induced glomerular endothelial and podocyte injury.
Authors: Oe Et al.
Sci.Rep. 2019;9:2986
Non-hematopoietic PAR-2 is essential for matriptase-driven pre-malignant progression and potentiation of ras-mediated squamous cell carcinogenesis.
Authors: Sales Et al.
Am J Physiol Cell Physiol 2015;34:346
Divergent β-arrestin-dependent signaling events are dependent upon sequences within G-protein-coupled receptor C termini.
Authors: Pal Et al.
J Biol Chem 2013;288:3265

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